DuBose Lyndsey E, Babcock Matthew C, Kohrt Wendy M, Stauffer Brian L, Hildreth Kerry L, Walker Jacob, Armstrong Matthew K, Moreau Kerrie L
Division of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, 12631 East 17th Ave., Mail Stop B179, Aurora, CO, 80045, USA.
Veterans Affairs Eastern Colorado Geriatric Research, Educational and Clinical Center (GRECC), Aurora, CO, USA.
Geroscience. 2024 Aug 7. doi: 10.1007/s11357-024-01293-y.
Hypogonadism is a risk factor for cardiovascular disease (CVD) in men related, in part, to increased oxidative stress. Elevated large artery stiffness and central pulsatile hemodynamics (e.g., pulse pressure and wave reflection magnitude) are independent risk factors for CVD. However, whether large artery stiffness and central pulsatile hemodynamics are (1) elevated in hypogonadal men independent of traditional CVD risk factors and (2) related to increased oxidative stress is unknown. Young men (N = 23; 30 ± 4 years) and middle-aged/older (MA/O) men with normal (> 400-1000 ng/dL; n = 57; 59 ± 7 years) or low testosterone (< 300 ng/dL; n = 21; 59 ± 7 years) underwent assessments of large artery stiffness (carotid ß-stiffness via ultrasonography) and central pulsatile hemodynamics (pulse wave analysis; SphygmoCor XCEL) following an infusion of saline or vitamin C to test the tonic suppression of vascular function by oxidative stress. Carotid stiffness differed by age (p < 0.001) and gonadal status within MA/O men (low testosterone vs. normal testosterone: 9.3 ± 0.7 vs. 8.0 ± 0.3U, p = 0.036). Central pulsatile hemodynamics did not differ by age or gonadal status (p > 0.119). Vitamin C did not alter carotid stiffness in any group (p > 0.171). There was a significant group × infusion interaction on aortic reflection magnitude (p = 0.015). Vitamin C treatment reduced aortic reflection magnitude in young and MA/O men with normal testosterone (both p < 0.001) but not MA/O men with low testosterone (p = 0.891). Collectively, hypogonadism may accelerate age-related large artery stiffening in MA/O men with low testosterone, independent of CVD risk factors; however, this is not related to increased reactive oxygen species sensitive to an acute vitamin C infusion.
性腺功能减退是男性心血管疾病（CVD）的一个危险因素，部分原因是氧化应激增加。大动脉僵硬度升高和中心脉搏血流动力学（如脉压和波反射幅度）是心血管疾病的独立危险因素。然而，大动脉僵硬度和中心脉搏血流动力学是否（1）在性腺功能减退男性中升高，且独立于传统心血管疾病危险因素，以及（2）与氧化应激增加有关，目前尚不清楚。年轻男性（N = 23；30±4岁）以及中年/老年（MA/O）男性，其睾酮水平正常（>400 - 1000 ng/dL；n = 57；59±7岁）或较低（<300 ng/dL；n = 21；59±7岁），在输注生理盐水或维生素C后，接受大动脉僵硬度（通过超声检查颈动脉β僵硬度）和中心脉搏血流动力学（脉搏波分析；SphygmoCor XCEL）评估，以测试氧化应激对血管功能的紧张性抑制作用。颈动脉僵硬度在年龄上存在差异（p < 0.001），在MA/O男性中也因性腺状态不同而有差异（低睾酮组与正常睾酮组：9.3±0.7 vs. 8.0±0.3U，p = 0.036）。中心脉搏血流动力学在年龄或性腺状态方面没有差异（p > 0.119）。维生素C在任何组中均未改变颈动脉僵硬度（p > 0.171）。在主动脉反射幅度上存在显著的组×输注交互作用（p = 0.015）。维生素C治疗降低了睾酮水平正常的年轻男性和MA/O男性的主动脉反射幅度（两者p < 0.001），但对睾酮水平较低的MA/O男性没有影响（p = 0.891）。总体而言，性腺功能减退可能会加速睾酮水平较低的MA/O男性与年龄相关的大动脉僵硬化，且独立于心血管疾病危险因素；然而，这与对急性维生素C输注敏感的活性氧增加无关。
