Ishida K, Hinshaw L B, Totsuka M, Hayasaka H
Nihon Geka Gakkai Zasshi. 1985 Dec;86(12):1584-9.
We postulate that high plasma concentrations of gastrointestinal-derived glucagon may be used to identify severe sepsis and correlate with the effect of therapy. Eighteen adult dogs were separated into three groups: Group I-LD100 E. coli alone, group II-LD100 E. coli + tobramycin (TOB) and group III-LD100 E. coli + TOB + methylprednisolone sodium succinate (MPSS). E. coli was infused intravenously for one hour. Each animal was monitored for six hours and observed for a 7-day recovery period. Percent survival (greater than 7 days): I = 0%, II = 17% and III = 83%. Concentrations of gastrointestinal glucagon were 3417 pg/ml in group I, 5167 pg/ml in group II and 1081 pg/ml in group III at six hours after E. coli infusion. In group III these concentration returned to control values by 7 days after E. coli infusion. Increases in gastrointestinal glucagon were more readily induced by E. coli infusion than those of pancreatic glucagon. Gastrointestinal glucagon concentrations were related to the severity of E. coli induced shock and the beneficial effects of MPSS/TOB therapy. Therefore, plasma gastrointestinal glucagon concentrations may be useful in recognizing the presence of severe sepsis and directly related to the beneficial effects of therapy.
我们推测，高血浆浓度的胃肠道源性胰高血糖素可用于识别严重脓毒症，并与治疗效果相关。18只成年犬被分为三组：第一组单独注射LD100剂量的大肠杆菌，第二组注射LD100剂量的大肠杆菌+妥布霉素（TOB），第三组注射LD100剂量的大肠杆菌+TOB+琥珀酸钠甲泼尼龙（MPSS）。静脉输注大肠杆菌1小时。对每只动物监测6小时，并观察7天的恢复期。存活率（大于7天）：第一组=0%，第二组=17%，第三组=83%。大肠杆菌输注后6小时，第一组胃肠道胰高血糖素浓度为3417 pg/ml，第二组为5167 pg/ml，第三组为1081 pg/ml。在第三组中，这些浓度在大肠杆菌输注后7天恢复到对照值。与胰腺胰高血糖素相比，大肠杆菌输注更容易诱导胃肠道胰高血糖素增加。胃肠道胰高血糖素浓度与大肠杆菌诱导的休克严重程度以及MPSS/TOB治疗的有益效果相关。因此，血浆胃肠道胰高血糖素浓度可能有助于识别严重脓毒症的存在，并与治疗的有益效果直接相关。
