Li Xiongjuan, Zhao Zhao, Ke Yuwen, Jiang Yonghan, Liu Yuqiang, Liu Zhiheng
From the Department of Anesthesiology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen, China.
Anesth Analg. 2025 Mar 1;140(3):616-627. doi: 10.1213/ANE.0000000000007096. Epub 2024 Aug 7.
One of the functions of organism cells is to maintain energy homeostasis to promote metabolism and adapt to the environment. The 3 major pathways of cellular energy metabolism are glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation (OXPHOS). Neurons, astrocytes, and microglia are crucial in allodynia, hyperalgesia, and sensitization in nociceptive pathways. This review focused on these 3 major cellular energy metabolism pathways, aiming to elucidate the relationship between neurocyte and pain sensation and present the reprogramming of energy metabolism on pain, as well as the cellular and molecular mechanism underlying various forms of pain. The clinical and preclinical drugs involved in pain treatment and molecular mechanisms via cellular energy metabolism were also discussed.
机体细胞的功能之一是维持能量稳态，以促进新陈代谢并适应环境。细胞能量代谢的3条主要途径是糖酵解、三羧酸（TCA）循环和氧化磷酸化（OXPHOS）。神经元、星形胶质细胞和小胶质细胞在伤害性感受通路的异常性疼痛、痛觉过敏和敏化中起关键作用。本综述聚焦于这3条主要的细胞能量代谢途径，旨在阐明神经细胞与痛觉之间的关系，介绍疼痛时能量代谢的重编程以及各种疼痛形式背后的细胞和分子机制。还讨论了涉及疼痛治疗的临床和临床前药物以及通过细胞能量代谢的分子机制。
