Department of Respiratory and Critical Care Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Beijing Key Laboratory of Diabetes Research and Care, Department of Endocrinology, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
PLoS One. 2024 Aug 7;19(8):e0308148. doi: 10.1371/journal.pone.0308148. eCollection 2024.
Chronic obstructive pulmonary disease (COPD) has emerged as a leading cause of chronic disease morbidity and mortality globally, posing a substantial public health challenge. Perfluoroalkyl substances (PFAS) are synthetic chemicals known for their high stability and durability. Research has examined their potential link to decreased lung function. Physical activity (PA) has been identified as one of the primary modalities of the non-pharmacological treatment of COPD.
To investigate the relationship between PFAS and COPD, and whether physical activity could reduce the risk of COPD caused by PFAS exposure, we used data from the NHANES 2013-2018, a cross-sectional study. Logistic regression analysis was used to examine the associations between PFAS and COPD in adult populations, and their associations in different PA types.
We finally included 4857 participants in the analysis, and found that Sm-PFOS (OR: 1.250), PFOA (OR: 1.398) and n-PFOA (OR: 1.354) were closely related to COPD; After stratified by gender, age and smoking, the results showed that Sm-PFOA (OR: 1.312) was related to COPD in female adult, and PFOA (OR: 1.398) and n-PFOA (OR: 1.354) were associated with COPD in male adults; The associations of Sm-PFOS (OR: 1.280), PFOA (OR: 1.481) and n-PFOA (OR: 1.424)with COPD tended to be stronger and more consistent in over 50 years old adults; Sm-PFOS was related to COPD in current smoker (OR: 1.408), and PFOA was related to COPD in former smoker (OR: 1.487); Besides, in moderate-intensity PA group, there were no associations of Sm-PFOS, PFOA and n-PFOA with COPD stratified by gender, age and smoking.
PFAS exposure may increase the risk of developing COPD, but regular moderate-intensity physical activity can protect individuals from evolving to the disease. However, longitudinal studies are needed to support these preliminary findings.
慢性阻塞性肺疾病（COPD）已成为全球慢性疾病发病率和死亡率的主要原因之一，对公共健康构成了重大挑战。全氟烷基物质（PFAS）是稳定性和耐用性都很高的合成化学品。研究已经研究了它们与肺功能下降之间的潜在联系。身体活动（PA）已被确定为 COPD 的非药物治疗的主要方式之一。
为了研究 PFAS 与 COPD 之间的关系，以及身体活动是否可以降低 PFAS 暴露引起的 COPD 风险，我们使用了 2013-2018 年 NHANES 的数据，这是一项横断面研究。逻辑回归分析用于检查成年人群中 PFAS 与 COPD 之间的关联，以及不同 PA 类型中的关联。
我们最终纳入了 4857 名参与者进行分析，发现 Sm-PFOS（OR：1.250）、PFOA（OR：1.398）和 n-PFOA（OR：1.354）与 COPD 密切相关；按性别、年龄和吸烟分层后，结果表明，Sm-PFOA（OR：1.312）与成年女性的 COPD 有关，而 PFOA（OR：1.398）和 n-PFOA（OR：1.354）与成年男性的 COPD 有关；Sm-PFOS（OR：1.280）、PFOA（OR：1.481）和 n-PFOA（OR：1.424）与 COPD 的关联在 50 岁以上的成年人中更为强烈和一致；Sm-PFOS 与当前吸烟者的 COPD 有关（OR：1.408），而 PFOA 与前吸烟者的 COPD 有关（OR：1.487）；此外，在中等强度 PA 组中，按性别、年龄和吸烟分层，Sm-PFOS、PFOA 和 n-PFOA 与 COPD 之间均无关联。
PFAS 暴露可能会增加患 COPD 的风险，但定期进行适度的身体活动可以保护个人免受疾病的影响。然而，需要进行纵向研究来支持这些初步发现。
