Department of Chemistry, The University of Lahore, Lahore 54000, Pakistan.
Department of Chemistry, The University of Lahore, Lahore 54000, Pakistan.
Int J Biol Macromol. 2024 Oct;278(Pt 1):134172. doi: 10.1016/j.ijbiomac.2024.134172. Epub 2024 Aug 5.
Chitosan has established itself as a multifunctional and auspicious biomaterial within the domain of tissue engineering, presenting a decade of uninterrupted advancements and novel implementations. This article provides a comprehensive overview of the most recent developments in chitosan-based tissue engineering, focusing on significant progress made in the last ten years. An exploration is conducted of the various techniques utilized in the modification of chitosan and the production of scaffolds, with an analysis of their effects on cellular reactions and tissue regeneration. The investigation focuses on the integration of chitosan with other biomaterials and the addition of bioactive agents to improve their functionalities. Upon careful analysis of the in vitro and in vivo research, it becomes evident that chitosan effectively stimulates cell adhesion, proliferation, and differentiation. Furthermore, we offer valuable perspectives on the dynamic realm of chitosan-based approaches tailored to distinct tissue categories, including nerve, bone, cartilage, and skin. The review concludes with a discussion of prospective developments, with particular attention given to possible directions for additional study, translational implementations, and the utilization of chitosan to tackle existing obstacles in the field of tissue engineering. This extensive examination provides a significant amalgamation of the advancements achieved over the previous decade and directs scholars towards uncharted territories in chitosan-based tissue engineering.
壳聚糖作为组织工程领域中的一种多功能、有前途的生物材料，已经确立了自己的地位，在过去十年中不断取得进展和新的应用。本文全面概述了基于壳聚糖的组织工程的最新发展，重点介绍了过去十年中取得的重大进展。探讨了壳聚糖修饰和支架制备中使用的各种技术，并分析了它们对细胞反应和组织再生的影响。研究集中于壳聚糖与其他生物材料的整合以及添加生物活性物质以提高其功能。通过对体外和体内研究的仔细分析，显然壳聚糖能有效刺激细胞黏附、增殖和分化。此外，我们还提供了有关针对不同组织类型（包括神经、骨骼、软骨和皮肤）的基于壳聚糖的方法的有价值的观点。本文最后讨论了未来的发展方向，特别关注可能的进一步研究方向、转化应用以及利用壳聚糖解决组织工程领域现有障碍的方向。这一广泛的研究对过去十年取得的进展进行了重要的综合，并为基于壳聚糖的组织工程领域的学者指明了未探索的领域。
