Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India.
Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India.
Int J Biol Macromol. 2018 Nov;119:1228-1239. doi: 10.1016/j.ijbiomac.2018.08.056. Epub 2018 Aug 11.
In the recent years, a paradigm shift is taking place where metallic/synthetic implants and tissue grafts are being replaced by tissue engineering approach. A well designed three-dimensional scaffold is one of the fundamental tools to guide tissue formation in vitro and in vivo. Bone is a highly dynamic and an integrative tissue, and thus enormous efforts have been invested in bone tissue engineering to design a highly porous scaffold which plays a critical role in guiding bone growth and regeneration. Numerous techniques have been developed to fabricate highly interconnected, porous scaffold for bone tissue engineering applications with the help of biomolecules such as chitosan, collagen, gelatin, silk, etc. We aim, in this review, to provide an overview of different types of fabrication techniques for scaffold preparation in bone tissue engineering using biological macromolecules.
近年来，一种范式转变正在发生，其中金属/合成植入物和组织移植物正在被组织工程方法所取代。设计良好的三维支架是指导体外和体内组织形成的基本工具之一。骨骼是一种高度动态和综合的组织，因此，人们投入了大量的精力来设计高度多孔的支架，以指导骨骼生长和再生。已经开发了许多技术来制备具有高度互连的多孔支架，用于骨组织工程应用，这些支架在生物分子的帮助下制备，例如壳聚糖、胶原、明胶、丝等。在这篇综述中，我们旨在概述使用生物大分子制备骨组织工程支架的不同类型的制造技术。
