Molecular Endocrinology Unit, KMEB, Department of Endocrinology, Odense University Hospital, Winsløws Vej 4, Odense C 5000, Denmark.
Molecular Endocrinology Unit, KMEB, Department of Endocrinology, Odense University Hospital, Winsløws Vej 4, Odense C 5000, Denmark; Institute of Cellular and Molecular Medicine (ICMM), Panum Institute, University of Copenhagen, 3B Blegdamsvej, Copenhagen N 2200, Denmark.
Mech Ageing Dev. 2024 Oct;221:111976. doi: 10.1016/j.mad.2024.111976. Epub 2024 Aug 5.
Human aging is linked to bone loss, resulting in bone fragility and an increased risk of fractures. This is primarily due to an age-related decline in the function of bone-forming osteoblastic cells and accelerated cellular senescence within the bone microenvironment. Here, we provide a detailed discussion of the hypothesis that age-related defective bone formation is caused by senescence of skeletal stem cells, as they are the main source of bone forming osteoblastic cells and influence the composition of bone microenvironment. Furthermore, this review discusses potential strategies to target cellular senescence as an emerging approach to treat age-related bone loss.
人类衰老与骨丢失有关，导致骨骼脆弱和骨折风险增加。这主要是由于与年龄相关的成骨细胞功能下降以及骨骼微环境中细胞衰老加速所致。在这里，我们详细讨论了这样一种假设，即与年龄相关的骨形成缺陷是由骨骼干细胞衰老引起的，因为它们是形成骨的成骨细胞的主要来源，并影响骨骼微环境的组成。此外，本文还讨论了以细胞衰老为靶点的潜在策略，这是一种治疗与年龄相关的骨丢失的新兴方法。
