Kamijo Yui, Usuda Maho, Matsuno Atsuhiro, Katoh Nagaaki, Morita Yuki, Tamaru Fuyuhiko, Kasamatsu Hirotsugu, Sekijima Yoshiki
Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
Department of Neurology, Nagano Prefectural Rehabilitation Center, Japan.
Intern Med. 2025 Mar 1;64(5):775-779. doi: 10.2169/internalmedicine.3593-24. Epub 2024 Aug 8.
A 25-year-old Japanese man developed visual disturbance with eye pain and was diagnosed with optic neuritis associated with anti-myelin oligodendrocyte glycoprotein antibodies. His symptoms improved temporarily after steroid therapy but chronically relapsed many times after tapering the steroid dose. He became highly steroid-dependent and was referred to our department for reconsideration of the treatment strategy. Maintenance intravenous immunoglobulin (IVIg) therapy successfully decreased the annual recurrence rate from 1.15 to 0.27 times/year and the maintenance dose of oral prednisolone from 35 to 5 mg/day. Maintenance IVIg therapy is a promising option for preventing disease relapse in such cases.
一名25岁的日本男性出现视力障碍并伴有眼痛，被诊断为与抗髓鞘少突胶质细胞糖蛋白抗体相关的视神经炎。类固醇治疗后他的症状暂时改善，但在逐渐减少类固醇剂量后病情多次慢性复发。他对类固醇产生了高度依赖，随后被转诊至我们科室重新考虑治疗策略。维持性静脉注射免疫球蛋白（IVIg）治疗成功地将年复发率从每年1.15次降至0.27次，并将口服泼尼松龙的维持剂量从35毫克/天降至5毫克/天。对于预防此类病例的疾病复发，维持性IVIg治疗是一种有前景的选择。
