Administrative Office, Kailuan Mental Health Centre, Tangshan, Hebei, China.
The Fourth Ward, Kailuan Mental Health Centre, Tangshan, Hebei, China.
Sci Rep. 2024 Oct 15;14(1):24205. doi: 10.1038/s41598-024-67779-z.
This study aimed to evaluate the correlation between mental health status and arterial stiffness. A Symptom Checklist 90 (SCL-90) score was conducted for 10,688 employees of Kailuan Group Co., Ltd., of which 4936 participants received baPWV measurement. Of these, 4424 met the inclusion criteria. Based on the SCL-90 score, the study subjects were divided into normal mental health group (SCL-90 score < 160, 3993 cases) and abnormal mental health group (SCL-90 score ≥ 160, 431 cases). Statistical indicators include: General information, including levels of brachial-ankle pulse wave velocity (baPWV), age, gender, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), body mass index (BMI), smoking and alcohol consumption, daily activity levels, nature of work and educational qualifications. The proportion of males, baPWV value, and abnormal proportion of baPWV in normal mental health group were higher than those in abnormal mental health group (P < 0.05). The Hs-CRP in normal mental health group were lower than that in abnormal mental health group (P < 0.05). There were significant differences in activity level and educational attainment between the two groups (P < 0.05). After adjusting for confounders, the results of the multiple linear regression analysis showed that, Age, MAP, HR, FBG, TG were positively correlated with baPWV; SCL-90 score, gender, BMI, educational qualification were negatively correlated with baPWV. When the SCL-90 score of the general population increased by one point, baPWV decreased by 0.246 cm/s. Each such increase corresponded with a decrease in baPWV of 0.299 cm/s for male participants in general (β = - 0.299, P = 0.007) and 0.412 cm/s for the male participants in the older-age group (β = - 0.412, P = 0.017). Although adverse psychological factors have a certain impact on arterial stiffness, it does not constitute an independent risk factor.
本研究旨在评估心理健康状况与动脉僵硬度之间的相关性。对开滦集团有限公司的 10688 名员工进行症状自评量表 90（SCL-90）评分，其中 4936 名参与者接受了臂踝脉搏波速度（baPWV）测量。其中，4424 名符合纳入标准。根据 SCL-90 评分，研究对象分为正常心理健康组（SCL-90 评分<160，3993 例）和异常心理健康组（SCL-90 评分≥160，431 例）。统计指标包括：一般信息，包括臂踝脉搏波速度（baPWV）水平、年龄、性别、收缩压（SBP）、舒张压（DBP）、平均动脉压（MAP）、心率（HR）、体重指数（BMI）、吸烟和饮酒、日常活动水平、工作性质和教育程度。正常心理健康组中男性比例、baPWV 值和异常 baPWV 比例均高于异常心理健康组（P<0.05）。正常心理健康组的 Hs-CRP 低于异常心理健康组（P<0.05）。两组在活动水平和教育程度方面存在显著差异（P<0.05）。在调整混杂因素后，多元线性回归分析结果显示，年龄、MAP、HR、FBG、TG 与 baPWV 呈正相关；SCL-90 评分、性别、BMI、教育程度与 baPWV 呈负相关。当一般人群的 SCL-90 评分增加 1 分时，baPWV 降低 0.246cm/s。对于一般男性参与者，SCL-90 评分每增加 1 分，baPWV 降低 0.299cm/s（β=-0.299，P=0.007）；对于年龄较大的男性参与者，SCL-90 评分每增加 1 分，baPWV 降低 0.412cm/s（β=-0.412，P=0.017）。尽管不良心理因素对动脉僵硬度有一定影响，但它不是独立的危险因素。
