Chen Jia, Hu Lidong, Li Ning, Deng Wei, Xu Xiaojie, Wang Ling, Zhao Kaiping, Lu Shuai, Liu Xuejiao, Cheng Xiaoguang, Jiang Xieyuan
Department of Endocrinology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, China.
Department of Rheumatology and Immunology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Nutr Metab (Lond). 2024 Aug 7;21(1):62. doi: 10.1186/s12986-024-00841-9.
This study aims to investigate the association of serum TSH with BMD in Chinese adults with normal thyroid function.
These participants were divided into tertiles based on serum TSH levels. Linear regression model and multinomial logistic regression models were used to analyze the associations of continuous BMD and categorical BMD with serum TSH, respectively.
In women younger than 60 years, BMD decreased with the increase of TSH at normal level, while in women older than 60 years, BMD increased with the increase of TSH at normal level; besides, the BMD of women younger than 60 years old was significantly higher than that of women over 60 years old (156.05 ± 39.34 mg/cm vs. 86.95 ± 29.51 mg/cm, P < 0.001). Linear regression results showed negative associations of BMD and normal TSH level in women with age younger than 60 years (β=-4.34, P < 0.001), but this inverse trend was observed in women over 60 years old (β = 2.04, P = 0.041). Both in men younger than 60 years and over 60 years old, BMD decreased with the increase of TSH at normal levels; besides, the BMD of men younger than 60 years was significantly higher than those over 60 years old (143.08 ± 32.76 mg/cm vs. 108.13 ± 31.99 mg/cm, P < 0.001).
The results demonstrated an opposite trend in BMD at normal TSH levels in younger and elder females, that is, in females younger than 60 years, BMD decreased with the increase of TSH, which indicated that TSH might play a different role in younger and elder females. However, this trend was not significant in males.
本研究旨在调查甲状腺功能正常的中国成年人血清促甲状腺激素（TSH）与骨密度（BMD）之间的关联。
根据血清TSH水平将这些参与者分为三分位数。分别使用线性回归模型和多项逻辑回归模型分析连续型BMD和分类BMD与血清TSH之间的关联。
在60岁以下女性中，正常水平下BMD随TSH升高而降低，而在60岁以上女性中，正常水平下BMD随TSH升高而升高；此外，60岁以下女性的BMD显著高于60岁以上女性（156.05±39.34mg/cm对86.95±29.51mg/cm，P<0.001）。线性回归结果显示，60岁以下女性BMD与正常TSH水平呈负相关（β=-4.34，P<0.001），但在60岁以上女性中观察到相反趋势（β=2.04，P=0.041）。在60岁以下和60岁以上男性中，正常水平下BMD均随TSH升高而降低；此外，60岁以下男性的BMD显著高于60岁以上男性（143.08±32.76mg/cm对108.13±31.99mg/cm，P<0.001）。
结果表明，年轻和老年女性在正常TSH水平下BMD呈现相反趋势，即60岁以下女性中，BMD随TSH升高而降低，这表明TSH在年轻和老年女性中可能发挥不同作用。然而，这种趋势在男性中不显著。
