氧化应激相关线粒体DNA释放引发的白癜风自身免疫反应开启了新的治疗策略。 - Suppr

Vitiligo auto-immune response upon oxidative stress-related mitochondrial DNA release opens up new therapeutic strategies.

作者信息

Sant'Anna-Silva Ana C B, Botton Thomas, Rossi Andrea, Dobner Jochen, Bzioueche Hanene, Thach Nguyen, Blot Lauriane, Pagnotta Sophie, Kleszczynski Konrad, Steinbrink Kerstin, Mazure Nathalie M, Rocchi Stéphane, Krutmann Jean, Passeron Thierry, Tulic Meri K

机构信息

Université Côte d'Azur, INSERM U1065, C3M, Nice, France.

IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.

出版信息

Clin Transl Med. 2024 Aug;14(8):e1810. doi: 10.1002/ctm2.1810.

DOI:10.1002/ctm2.1810

PMID:39113238

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11306283/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbee/11306283/7ef7ecccd602/CTM2-14-e1810-g004.jpg

相似文献

Vitiligo auto-immune response upon oxidative stress-related mitochondrial DNA release opens up new therapeutic strategies.氧化应激相关线粒体DNA释放引发的白癜风自身免疫反应开启了新的治疗策略。

Clin Transl Med. 2024 Aug;14(8):e1810. doi: 10.1002/ctm2.1810.

Increased levels of mitochondrial DNA copy number in patients with vitiligo.白癜风患者线粒体DNA拷贝数水平升高。

Clin Exp Dermatol. 2017 Oct;42(7):749-754. doi: 10.1111/ced.13185. Epub 2017 Sep 3.

Vitiligo: Focus on Clinical Aspects, Immunopathogenesis, and Therapy.白癜风：关注临床方面、免疫发病机制和治疗。

Clin Rev Allergy Immunol. 2018 Feb;54(1):52-67. doi: 10.1007/s12016-017-8622-7.

Mitochondrial DNA acquires immunogenicity on exposure to nitrosative stress in patients with vitiligo.白癜风患者线粒体DNA暴露于亚硝化应激时会获得免疫原性。

Hum Immunol. 2014 Oct;75(10):1053-61. doi: 10.1016/j.humimm.2014.09.003. Epub 2014 Sep 16.

Vitiligo: what's new in the psycho-neuro-endocrine-immune connection and related treatments.白癜风：心理-神经-内分泌-免疫关联及相关治疗的新进展

Wien Med Wochenschr. 2014 Jul;164(13-14):278-85. doi: 10.1007/s10354-014-0288-7. Epub 2014 Jul 25.

Vitiligo: auto-immunity and immune responses.白癜风：自身免疫与免疫反应。

Int J Dermatol. 2006 May;45(5):583-90. doi: 10.1111/j.1365-4632.2005.02651.x.

Re: Vitiligo: auto-immunity and immune responses.关于：白癜风：自身免疫与免疫反应。

Int J Dermatol. 2007 Dec;46(12):1314-5. doi: 10.1111/j.1365-4632.2007.03484.x.

Cytokines: the yin and yang of vitiligo pathogenesis.细胞因子：白癜风发病机制的阴阳两面。

Expert Rev Clin Immunol. 2019 Feb;15(2):177-188. doi: 10.1080/1744666X.2019.1550358. Epub 2018 Nov 30.

Physiopathology and genetics of vitiligo.白癜风的生理病理学与遗传学

J Autoimmun. 2005;25 Suppl:63-8. doi: 10.1016/j.jaut.2005.10.001. Epub 2005 Nov 18.

Oxidative Stress-Induced HMGB1 Release from Melanocytes: A Paracrine Mechanism Underlying the Cutaneous Inflammation in Vitiligo.黑素细胞氧化应激诱导的高迁移率族蛋白 B1 释放：白癜风皮肤炎症的旁分泌机制。

J Invest Dermatol. 2019 Oct;139(10):2174-2184.e4. doi: 10.1016/j.jid.2019.03.1148. Epub 2019 Apr 15.

引用本文的文献

Characterization of Gut Microbiota in Patients with Active Spreading Vitiligo Based on Whole-Genome Shotgun Sequencing.基于全基因组鸟枪法测序对活动性泛发性白癜风患者肠道微生物群的特征分析

Int J Mol Sci. 2025 Mar 24;26(7):2939. doi: 10.3390/ijms26072939.

本文引用的文献

Mitophagy and immune infiltration in vitiligo: evidence from bioinformatics analysis.自噬与免疫浸润在白癜风中的作用：生物信息学分析证据。

Front Immunol. 2023 May 23;14:1164124. doi: 10.3389/fimmu.2023.1164124. eCollection 2023.

Fumarate induces vesicular release of mtDNA to drive innate immunity.富马酸盐诱导线粒体 DNA 囊泡释放以驱动先天免疫。

Nature. 2023 Mar;615(7952):499-506. doi: 10.1038/s41586-023-05770-w. Epub 2023 Mar 8.

Analysis of Matched Skin and Gut Microbiome of Patients with Vitiligo Reveals Deep Skin Dysbiosis: Link with Mitochondrial and Immune Changes.分析白癜风患者的匹配皮肤和肠道微生物组揭示了深度皮肤失调：与线粒体和免疫变化的关联。

J Invest Dermatol. 2021 Sep;141(9):2280-2290. doi: 10.1016/j.jid.2021.01.036. Epub 2021 Mar 24.

Loss of Function of the Gene Encoding the Histone Methyltransferase KMT2D Leads to Deregulation of Mitochondrial Respiration.编码组蛋白甲基转移酶 KMT2D 的基因功能丧失导致线粒体呼吸失调。

Cells. 2020 Jul 13;9(7):1685. doi: 10.3390/cells9071685.

Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo.先天淋巴细胞诱导的 CXCR3B 介导的黑素细胞凋亡是白癜风中 T 细胞自身反应性的潜在启动子。

Nat Commun. 2019 May 16;10(1):2178. doi: 10.1038/s41467-019-09963-8.

Melatonin and its metabolites protect human melanocytes against UVB-induced damage: Involvement of NRF2-mediated pathways.褪黑素及其代谢产物可保护人类黑素细胞免受 UVB 诱导的损伤：涉及 NRF2 介导的途径。

Sci Rep. 2017 Apr 28;7(1):1274. doi: 10.1038/s41598-017-01305-2.

TLR3 and TLR4 But not TLR2 are Involved in Vogt-Koyanagi- Harada Disease by Triggering Proinflammatory Cytokines Production Through Promoting the Production of Mitochondrial Reactive Oxygen Species.Toll样受体3和Toll样受体4而非Toll样受体2通过促进线粒体活性氧的产生触发促炎细胞因子的产生而参与葡萄膜大脑炎。

Curr Mol Med. 2015;15(6):529-42. doi: 10.2174/1566524015666150731095611.

Human mitochondrial DNA: roles of inherited and somatic mutations.人类线粒体 DNA：遗传和体细胞突变的作用。

Nat Rev Genet. 2012 Dec;13(12):878-90. doi: 10.1038/nrg3275.

Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes.类风湿性关节炎滑膜细胞线粒体中的体细胞突变。

Arthritis Res Ther. 2005;7(4):R844-51. doi: 10.1186/ar1752. Epub 2005 Apr 28.

Increased prevalence of vitiligo, but no evidence of premature ageing, in the skin of patients with bp 3243 mutation in mitochondrial DNA in the mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome (MELAS).线粒体脑肌病、乳酸酸中毒和卒中样发作综合征（MELAS）中，线粒体DNA存在bp 3243突变的患者皮肤中白癜风患病率增加，但无早衰迹象。

Br J Dermatol. 1999 Apr;140(4):634-9. doi: 10.1046/j.1365-2133.1999.02761.x.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Vitiligo auto-immune response upon oxidative stress-related mitochondrial DNA release opens up new therapeutic strategies.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献检索

文件翻译

深度研究

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献