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Vitiligo auto-immune response upon oxidative stress-related mitochondrial DNA release opens up new therapeutic strategies.

作者信息

Sant'Anna-Silva Ana C B, Botton Thomas, Rossi Andrea, Dobner Jochen, Bzioueche Hanene, Thach Nguyen, Blot Lauriane, Pagnotta Sophie, Kleszczynski Konrad, Steinbrink Kerstin, Mazure Nathalie M, Rocchi Stéphane, Krutmann Jean, Passeron Thierry, Tulic Meri K

机构信息

Université Côte d'Azur, INSERM U1065, C3M, Nice, France.

IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.

出版信息

Clin Transl Med. 2024 Aug;14(8):e1810. doi: 10.1002/ctm2.1810.

DOI:10.1002/ctm2.1810
PMID:39113238
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11306283/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbee/11306283/1de1313cc7a0/CTM2-14-e1810-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbee/11306283/7ef7ecccd602/CTM2-14-e1810-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbee/11306283/bfb2552ee832/CTM2-14-e1810-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbee/11306283/dc7983d2d7a5/CTM2-14-e1810-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbee/11306283/1de1313cc7a0/CTM2-14-e1810-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbee/11306283/7ef7ecccd602/CTM2-14-e1810-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbee/11306283/bfb2552ee832/CTM2-14-e1810-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbee/11306283/dc7983d2d7a5/CTM2-14-e1810-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbee/11306283/1de1313cc7a0/CTM2-14-e1810-g003.jpg

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本文引用的文献

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Mitophagy and immune infiltration in vitiligo: evidence from bioinformatics analysis.自噬与免疫浸润在白癜风中的作用：生物信息学分析证据。
Front Immunol. 2023 May 23;14:1164124. doi: 10.3389/fimmu.2023.1164124. eCollection 2023.
2
Fumarate induces vesicular release of mtDNA to drive innate immunity.富马酸盐诱导线粒体 DNA 囊泡释放以驱动先天免疫。
Nature. 2023 Mar;615(7952):499-506. doi: 10.1038/s41586-023-05770-w. Epub 2023 Mar 8.
3
Analysis of Matched Skin and Gut Microbiome of Patients with Vitiligo Reveals Deep Skin Dysbiosis: Link with Mitochondrial and Immune Changes.
分析白癜风患者的匹配皮肤和肠道微生物组揭示了深度皮肤失调：与线粒体和免疫变化的关联。
J Invest Dermatol. 2021 Sep;141(9):2280-2290. doi: 10.1016/j.jid.2021.01.036. Epub 2021 Mar 24.
4
Loss of Function of the Gene Encoding the Histone Methyltransferase KMT2D Leads to Deregulation of Mitochondrial Respiration.编码组蛋白甲基转移酶 KMT2D 的基因功能丧失导致线粒体呼吸失调。
Cells. 2020 Jul 13;9(7):1685. doi: 10.3390/cells9071685.
5
Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo.先天淋巴细胞诱导的 CXCR3B 介导的黑素细胞凋亡是白癜风中 T 细胞自身反应性的潜在启动子。
Nat Commun. 2019 May 16;10(1):2178. doi: 10.1038/s41467-019-09963-8.
6
Melatonin and its metabolites protect human melanocytes against UVB-induced damage: Involvement of NRF2-mediated pathways.褪黑素及其代谢产物可保护人类黑素细胞免受 UVB 诱导的损伤：涉及 NRF2 介导的途径。
Sci Rep. 2017 Apr 28;7(1):1274. doi: 10.1038/s41598-017-01305-2.
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