University Institute of Pharma Sciences, Chandigarh University, Gharuan, Mohali, Punjab, India.
Department of Pharmaceutical Chemistry, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India.
Anticancer Agents Med Chem. 2024;24(19):1396-1406. doi: 10.2174/0118715206312324240805075050.
Germacrone, a naturally occurring active compound found in essential oils extracted from medicinal plants within the Zingiberaceae family, has garnered attention for its potential therapeutic applications. Extensive research has highlighted its multi-targeting capabilities, positioning it as a promising treatment for various chronic diseases, including cancer, cardiovascular conditions, and neurodegenerative disorders like Alzheimer's disease.
This review aims to provide a comprehensive overview of germacrone as a scaffold for developing multi-targeting drugs with therapeutic potential against a range of chronic disorders. The study delves into the molecular mechanisms that underlie the therapeutic effects of germacrone and explores its potential targets, including NF-κB, PI3K/AKT/mTOR, p53, JAK/STAT, caspase, apoptosis, and autophagy induction.
A systematic review of literature databases was conducted to gather relevant studies on germacrone and its therapeutic applications. The molecular mechanisms and potential targets of germacrone were examined to elucidate its multi-targeting capabilities.
Germacrone exhibits significant potential in the management of chronic diseases, with demonstrated effects on various cellular pathways. The review highlights its impact on NF-κB, PI3K/AKT/mTOR, p53, JAK/STAT, caspase, apoptosis, and autophagy induction, showcasing its versatility in targeting multiple pathways associated with chronic conditions. Germacrone has emerged as a promising candidate for the treatment of diverse chronic diseases. The understanding of its multi-targeting capabilities, coupled with its natural origin, positions it as a valuable scaffold for developing therapeutics.
The exploration of germacrone as a structural framework for multi-targeting drugs offers a potential avenue to enhance efficacy while minimizing potential side effects. Further research and clinical trials are warranted to validate the therapeutic potential of germacrone in diverse medical contexts.
倍半萜烯，一种天然存在的活性化合物，存在于姜科药用植物提取的精油中，因其潜在的治疗应用而受到关注。广泛的研究强调了它的多靶点作用，使其成为治疗各种慢性疾病的有前途的药物，包括癌症、心血管疾病和阿尔茨海默病等神经退行性疾病。
本综述旨在提供倍半萜烯作为开发具有治疗多种慢性疾病潜力的多靶点药物的支架的全面概述。研究深入探讨了倍半萜烯治疗作用的分子机制，并探讨了其潜在的靶点，包括 NF-κB、PI3K/AKT/mTOR、p53、JAK/STAT、半胱天冬酶、细胞凋亡和自噬诱导。
对文献数据库进行系统综述，以收集有关倍半萜烯及其治疗应用的相关研究。检查了倍半萜烯的分子机制和潜在靶点，以阐明其多靶点作用。
倍半萜烯在慢性疾病的管理中具有显著的潜力，对各种细胞途径表现出明显的效果。综述强调了其对 NF-κB、PI3K/AKT/mTOR、p53、JAK/STAT、半胱天冬酶、细胞凋亡和自噬诱导的影响，展示了其在靶向与慢性疾病相关的多种途径方面的多功能性。倍半萜烯已成为治疗多种慢性疾病的有希望的候选药物。对其多靶点作用的认识，加上其天然来源，使其成为开发治疗药物的有价值的支架。
探索倍半萜烯作为多靶点药物的结构框架为提高疗效同时最小化潜在副作用提供了潜在途径。需要进一步的研究和临床试验来验证倍半萜烯在不同医学背景下的治疗潜力。
