Laboratory of Physiopathology and Molecular Genetics, Department of Biology, Faculty of Sciences Ben M'Sik, Hassan II University, Casablanca, Morocco.
Anticancer Agents Med Chem. 2024;24(19):1383-1395. doi: 10.2174/0118715206314212240805105735.
The Prodiginins (PGs) natural pigments are secondary metabolites produced by a broad spectrum of gram-negative and gram-positive bacteria, notably by species within the Serratia and Streptomyces genera. These compounds exhibit diverse and potent biological activities, including anticancer, immunosuppressive, antimicrobial, antimalarial, and antiviral effects. Structurally, PGs share a common tripyrrolic core but possess variable side chains and undergo cyclization, resulting in structural diversity. Studies have investigated their antiproliferative effects on various cancer cell lines, with some PGs advancing to clinical trials for cancer treatment. This review aims to illuminate the molecular mechanisms underlying PG-induced apoptosis in cancer cells and explore the structure-activity relationships pertinent to their anticancer properties. Such insights may serve as a foundation for further research in anticancer drug development, potentially leading to the creation of novel, targeted therapies based on PGs or their derivatives.
普罗布考（PGs）天然色素是由广谱革兰氏阴性和革兰氏阳性细菌产生的次生代谢产物，特别是沙雷氏菌属和链霉菌属的某些物种。这些化合物具有多样且强效的生物活性，包括抗癌、免疫抑制、抗菌、抗疟和抗病毒作用。在结构上，PGs 具有共同的三吡咯核心，但具有可变的侧链，并经历环化，从而产生结构多样性。研究已经调查了它们对各种癌细胞系的抗增殖作用，一些 PGs 已进入癌症治疗的临床试验。本综述旨在阐明 PG 诱导癌细胞凋亡的分子机制，并探讨与抗癌特性相关的结构-活性关系。这些见解可以为抗癌药物开发的进一步研究提供基础，可能会基于 PG 或其衍生物创建新的靶向治疗方法。
