School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, P.R. China.
School of Biochemistry and Molecular Biology, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, P.R. China.
Anticancer Agents Med Chem. 2023;23(7):765-778. doi: 10.2174/1871520622666220831124321.
Historically, natural plant-derived drugs received a great impact of consideration in the treatment of several human-associated disorders. Cancer is a devastating disease and the second most cause of mortality. Sanguinarine (SANG), a naturally isolated plant alkaloidal agent, possesses chemo-preventive effects. Several studies have revealed that SANG impedes tumor metastasis and development by disrupting a wide range of cell signaling pathways and its molecular targets, such as BCL-2, MAPKs, Akt, NF-κB, ROS, and microRNAs (miRNAs). However, its low chemical stability and poor oral bioavailability remain key issues in its use as a medicinal molecule. A novel method (e.g., liposomes, nanoparticles, and micelles) and alternative analogs provide an exciting approach to alleviate these problems and broaden its pharmacokinetic profile. Cancer-specific miRNA expression is synchronized by SANG, which has also been uncertain. In this critical study, we review the utilization of SANG mimics and nano-technologies to improve its support in cancer. We focus on recently disclosed studies on SANG anti-cancer properties.
从历史上看，天然植物衍生药物在治疗多种人类相关疾病方面受到了极大的关注。癌症是一种毁灭性的疾病，是第二大死亡原因。血根碱（SANG）是一种天然分离的植物生物碱，具有化学预防作用。多项研究表明，SANG 通过破坏广泛的细胞信号通路及其分子靶点，如 BCL-2、MAPKs、Akt、NF-κB、ROS 和 microRNAs（miRNAs），阻碍肿瘤转移和发展。然而，其化学稳定性低和口服生物利用度差仍然是其作为药用分子使用的关键问题。一种新的方法（例如脂质体、纳米粒子和胶束）和替代类似物为缓解这些问题和拓宽其药代动力学特征提供了令人兴奋的方法。SANG 还同步了癌症特异性 miRNA 的表达，这一点也不确定。在这项重要的研究中，我们回顾了 SANG 模拟物和纳米技术的利用，以改善其在癌症中的应用。我们重点介绍了最近关于 SANG 抗癌特性的研究。
