Han Jialei, Duan Ziwei, Liu Changjiang, Liu Yadong, Zhao Xinyu, Wang Bo, Cao Shuaishuai, Wu Dalin
School of Biomedical Engineering, Sun Yat-Sen University of Shenzhen Campus, Shenzhen 518107, China.
Shenzhen University General Hospital, Shenzhen 518055, China.
Biomacromolecules. 2024 Sep 9;25(9):5860-5872. doi: 10.1021/acs.biomac.4c00548. Epub 2024 Aug 7.
F magnetic resonance imaging (F MRI) is gaining attention as an emerging diagnostic technology. Effective F MRI contrast agents (CAs) for in vivo applications require a long transverse (or spin-spin) relaxation time (), short longitudinal (or spin-lattice) relaxation time (), high fluorine content, and excellent biocompatibility. Here, we present a novel hyperbranched polymeric F MRI CA based on β-cyclodextrin and phosphorylcholine. The influence of the branching degree and fluorine content on was thoroughly investigated. Results demonstrated a maximum fluorine content of 11.85% and a of 612 ms. This hyperbranched polymeric F MRI CA exhibited both great biocompatibility against cells and organs of mice and high-performance imaging capabilities both in vitro and in vivo. The research provides positive insights into the synthesis strategies, topological design, and selection of fluorine tags for F MRI CAs.
氟磁共振成像（F MRI）作为一种新兴的诊断技术正受到关注。用于体内应用的有效F MRI造影剂（CAs）需要长横向（或自旋 - 自旋）弛豫时间（）、短纵向（或自旋 - 晶格）弛豫时间（）、高氟含量和优异的生物相容性。在此，我们提出了一种基于β - 环糊精和磷酸胆碱的新型超支化聚合物F MRI造影剂。深入研究了支化度和氟含量对的影响。结果表明最大氟含量为11.85%，为612毫秒。这种超支化聚合物F MRI造影剂对小鼠的细胞和器官均表现出良好的生物相容性，并且在体外和体内都具有高性能成像能力。该研究为F MRI造影剂的合成策略、拓扑设计和氟标记选择提供了积极的见解。
