Department of Materials, Molecular Sciences Research Hub, Imperial College London, 82 Wood Ln, London W12 0BZ, UK.
UCL Healthcare Biomagnetic and Nanomaterials Laboratories, 21 Albemarle Street, London W1S 4BS, UK.
Nanoscale. 2024 Aug 22;16(33):15446-15464. doi: 10.1039/d4nr02058h.
Hyperthermia and chemotherapy represent potential modalities for cancer treatments. However, hyperthermia can be invasive, while chemotherapy drugs often have severe side effects. Recent clinical investigations have underscored the potential synergistic efficacy of combining hyperthermia with chemotherapy, leading to enhanced cancer cell killing. In this context, magnetic iron oxide nanogels have emerged as promising candidates as they can integrate superparamagnetic iron oxide nanoparticles (IONPs), providing the requisite magnetism for magnetic hyperthermia, with the nanogel scaffold facilitating smart drug delivery. This review provides an overview of the synthetic methodologies employed in fabricating magnetic nanogels. Key properties and designs of these nanogels are discussed and challenges for their translation to the clinic and the market are summarised.
热疗和化疗代表了癌症治疗的潜在方式。然而，热疗具有侵入性，而化疗药物通常具有严重的副作用。最近的临床研究强调了将热疗与化疗相结合的潜在协同疗效，从而增强了癌细胞的杀伤效果。在这种情况下，磁性氧化铁纳米凝胶作为一种很有前途的候选材料脱颖而出，因为它们可以将超顺磁氧化铁纳米粒子（IONPs）整合在一起，为磁热疗提供必要的磁性，同时纳米凝胶支架促进智能药物输送。本综述概述了用于制备磁性纳米凝胶的合成方法。讨论了这些纳米凝胶的关键性质和设计，并总结了将它们转化为临床和市场的挑战。
