Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea.
Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea; Division of Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea.
Acta Biomater. 2016 Feb;31:122-133. doi: 10.1016/j.actbio.2015.12.015. Epub 2015 Dec 10.
UNLABELLED: The study describes the design and synthesis of an implantable smart magnetic nanofiber device for endoscopic hyperthermia treatment and tumor-triggered controlled drug release. This device is achieved using a two-component smart nanofiber matrix from monodisperse iron oxide nanoparticles (IONPs) as well as bortezomib (BTZ), a chemotherapeutic drug. The IONP-incorporated nanofiber matrix was developed by electrospinning a biocompatible and bioresorbable polymer, poly (d,l-lactide-co-glycolide) (PLGA), and tumor-triggered anticancer drug delivery is realized by exploiting mussel-inspired surface functionalization using 2-(3,4-dihydroxyphenyl)ethylamine (dopamine) to conjugate the borate-containing BTZ anticancer drug through a catechol metal binding in a pH-sensitive manner. Thus, an implantable smart magnetic nanofiber device can be exploited to both apply hyperthermia with an alternating magnetic field (AMF) and to achieve cancer cell-specific drug release to enable synergistic cancer therapy. These results confirm that the BTZ-loaded mussel-inspired magnetic nanofiber matrix (BTZ-MMNF) is highly beneficial not only due to the higher therapeutic efficacy and low toxicity towards normal cells but also, as a result of the availability of magnetic nanoparticles for repeated hyperthermia application and tumor-triggered controlled drug release. STATEMENT OF SIGNIFICANCE: The current work report on the design and development of a smart nanoplatform responsive to a magnetic field to administer both hyperthermia and pH-dependent anticancer drug release for the synergistic anticancer treatment. The iron oxide nanoparticles (IONPs) incorporated nanofiber matrix was developed by electrospinning a biocompatible polymer, poly (d,l-lactide-co-glycolide) (PLGA), and tumor-triggered anticancer drug delivery is realized by surface functionalization using 2-(3,4-dihydroxyphenyl)ethylamine (dopamine) to conjugate the boratecontaining anticancer drug bortezomib through a catechol metal binding in a pH-sensitive manner. This implantable magnetic nanofiber device can be exploited to apply hyperthermia with an alternating magnetic field and to achieve cancer cell-specific drug release to enable synergistic cancer therapy, which results in an improvement in both quality of life and patient compliance.
未加标签：本研究描述了一种可植入智能磁性纳米纤维装置的设计和合成，用于内窥镜热疗和肿瘤触发的控制药物释放。该装置采用单分散氧化铁纳米粒子（IONP）和硼替佐米（BTZ）的两组件智能纳米纤维基质实现，BTZ 是一种化疗药物。IONP 掺入的纳米纤维基质通过静电纺丝生物相容性和可生物降解的聚合物聚（D，L-丙交酯-共-乙交酯）（PLGA）来开发，并且通过利用贻贝启发的表面功能化来实现肿瘤触发的抗癌药物释放利用 2-（3,4-二羟基苯基）乙胺（多巴胺）以 pH 敏感的方式通过儿茶酚金属结合将含硼酸的 BTZ 抗癌药物缀合到硼酸盐中。因此，可以利用可植入的智能磁性纳米纤维装置来施加交变磁场（AMF）的热疗和实现癌细胞特异性药物释放，以实现协同癌症治疗。这些结果证实，负载硼替佐米的贻贝启发式磁性纳米纤维基质（BTZ-MMNF）不仅由于对正常细胞的更高治疗效果和低毒性而非常有益，而且由于可用于重复热疗应用和肿瘤触发的控制药物释放的磁性纳米颗粒的可用性。 意义声明：目前的工作报告了一种智能纳米平台的设计和开发，该平台对磁场有响应，可用于管理热疗和 pH 依赖性抗癌药物释放，以实现协同抗癌治疗。氧化铁纳米粒子（IONP）掺入的纳米纤维基质通过静电纺丝生物相容性聚合物聚（D，L-丙交酯-共-乙交酯）（PLGA）来开发，并且通过利用 2-（3,4-二羟基苯基）乙胺（多巴胺）的表面功能化来实现肿瘤触发的抗癌药物释放通过儿茶酚金属结合以 pH 敏感的方式将含硼酸的抗癌药物硼替佐米缀合。这种可植入的磁性纳米纤维装置可用于施加交变磁场的热疗和实现癌细胞特异性药物释放，以实现协同癌症治疗，从而提高生活质量和患者依从性。
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