Straub P W
Schweiz Med Wochenschr. 1985 Dec 7;115(49):1753-9.
Acute and chronic alcohol intoxication may lead to various types of corpuscular hemolytic anemias, irrespective of other coexisting organ damage such as liver cirrhosis. It also suppresses hemopoiesis in the bone marrow, leading to hyporegenerative anemia and to a pathogenetically unclear red cell macrocytosis, which in turn represents a sensitive and valuable index for occult alcoholism. Alcohol also suppresses platelet production. Acute intoxication may, furthermore, lead to reversible thrombocytopenia due to platelet sequestration. Platelet function is affected by alcohol both in vitro and in vivo, the defect being similar to that provoked by aspirin. The impaired host defense in chronic alcoholism is not yet adequately explained. It appears to be based on depression of bone marrow granulocyte reserve, granulocyte mobilization and granulocyte function, and also on impressive functional abnormalities of the lympho-plasmocellular system. The clinical relevance of alcohol-mediated hematological changes has not yet been sufficiently defined. It is certainly underestimated.
急性和慢性酒精中毒可能导致各种类型的红细胞溶血性贫血，无论是否存在其他并存的器官损害，如肝硬化。它还会抑制骨髓造血，导致再生低下性贫血以及病因不明的红细胞大细胞症，而后者反过来又是隐匿性酒精中毒的一个敏感且有价值的指标。酒精还会抑制血小板生成。此外，急性中毒可能由于血小板扣押导致可逆性血小板减少。酒精在体外和体内都会影响血小板功能，其缺陷类似于阿司匹林引起的缺陷。慢性酒精中毒中宿主防御受损的情况尚未得到充分解释。这似乎是基于骨髓粒细胞储备、粒细胞动员和粒细胞功能的抑制，以及淋巴细胞 - 浆细胞系统明显的功能异常。酒精介导的血液学变化的临床相关性尚未得到充分界定。它肯定被低估了。
