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皮肤学难题:认识嗜酸性粒细胞增多和全身症状的药物反应(DRESS)在有色人种患者皮肤中的皮肤表现的重要性。

A Dermatological Dilemma: The Importance of Recognizing Dermatologic Manifestations of Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) in Skin of Color Patients.

作者信息

Qadir Nadim A, Marsalisi Christopher, Reddy Anvit D, Stachler Luke, Onteddu Nirmal

机构信息

Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.

出版信息

Cureus. 2024 Jul 8;16(7):e64061. doi: 10.7759/cureus.64061. eCollection 2024 Jul.

DOI:10.7759/cureus.64061
PMID:39114221
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11305447/
Abstract

Many dermatologic conditions that are seen in medical literature are typically on lighter skin tones making it easier to identify. This can pose a difficult problem in the care of skin of color patients. The purpose of this paper is to highlight the importance of dermatologic manifestations in skin of color patients and the disparities that exist in the medical field. Here, we present the case of a 51-year-old African American male who was hospitalized on a prolonged course of antibiotics found to have drug reaction with eosinophilia and systemic symptoms (DRESS). Although the initial diagnosis was not made at symptom onset due to the atypical presentation in darker skin tones, the patient improved when the diagnosis was eventually made with cessation of the offending agent and steroid therapy. There is a vital need for continued awareness of the disparities that exist within medical literature and the medical field in regard to skin of color patients.

摘要

医学文献中记载的许多皮肤病通常在肤色较浅的人群中更易识别。这在有色人种患者的皮肤护理中可能会带来难题。本文旨在强调有色人种患者皮肤病表现的重要性以及医学领域中存在的差异。在此,我们呈现一例51岁非裔美国男性病例,该患者因长期使用抗生素住院,被发现患有药物超敏反应伴嗜酸性粒细胞增多和全身症状(DRESS)。尽管由于深色皮肤的非典型表现,在症状出现时未做出初始诊断,但在最终诊断并停用致病药物及进行类固醇治疗后,患者病情有所改善。迫切需要持续关注医学文献和医学领域中针对有色人种患者存在的差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/11305447/b489b557ddf2/cureus-0016-00000064061-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/11305447/ce239946e77f/cureus-0016-00000064061-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/11305447/3b4045f238a0/cureus-0016-00000064061-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/11305447/0f2d5baa11af/cureus-0016-00000064061-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/11305447/c151bcde9d7d/cureus-0016-00000064061-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/11305447/c8dc4a4693ac/cureus-0016-00000064061-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/11305447/b489b557ddf2/cureus-0016-00000064061-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/11305447/ce239946e77f/cureus-0016-00000064061-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/11305447/3b4045f238a0/cureus-0016-00000064061-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/11305447/0f2d5baa11af/cureus-0016-00000064061-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/11305447/c151bcde9d7d/cureus-0016-00000064061-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/11305447/c8dc4a4693ac/cureus-0016-00000064061-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/11305447/b489b557ddf2/cureus-0016-00000064061-i06.jpg

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A Dermatological Dilemma: The Importance of Recognizing Dermatologic Manifestations of Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) in Skin of Color Patients.皮肤学难题:认识嗜酸性粒细胞增多和全身症状的药物反应(DRESS)在有色人种患者皮肤中的皮肤表现的重要性。
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本文引用的文献

1
Increased mortality among African American patients with DRESS syndrome compared to White patients.与白人患者相比,患有药物超敏反应伴嗜酸性粒细胞增多和系统症状(DRESS)综合征的非裔美国患者死亡率更高。
Int J Dermatol. 2024 Mar;63(3):e80-e81. doi: 10.1111/ijd.16988. Epub 2023 Dec 15.
2
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in childhood: a narrative review.儿童药物疹伴嗜酸性粒细胞增多和全身症状(DRESS)综合征:一篇叙述性综述
Front Med (Lausanne). 2023 Jul 28;10:1108345. doi: 10.3389/fmed.2023.1108345. eCollection 2023.
3
Drug Reaction With Eosinophilia and Systemic Symptoms.
药物超敏反应伴嗜酸性粒细胞增多和全身症状
JAMA Dermatol. 2023 Mar 1;159(3):348. doi: 10.1001/jamadermatol.2022.4519.
4
Racial disparities in dermatology.皮肤科的种族差异。
Arch Dermatol Res. 2023 Jul;315(5):1215-1223. doi: 10.1007/s00403-022-02507-z. Epub 2022 Dec 12.
5
Discriminating minor and major forms of drug reaction with eosinophilia and systemic symptoms: Facial edema aligns to the severe phenotype.鉴别伴有嗜酸性粒细胞增多和全身症状的药物反应的轻、重形式:面部水肿与严重表型一致。
J Am Acad Dermatol. 2021 Sep;85(3):645-652. doi: 10.1016/j.jaad.2021.04.020. Epub 2021 Apr 16.
6
Current Perspective Regarding the Immunopathogenesis of Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms (DIHS/DRESS).当前对药物诱导的超敏反应综合征/药物伴嗜酸性粒细胞增多和全身症状(DIHS/DRESS)的免疫发病机制的看法。
Int J Mol Sci. 2021 Feb 21;22(4):2147. doi: 10.3390/ijms22042147.
7
Complicated Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome History in a 14-Year-Old.一名14岁患者的伴有嗜酸性粒细胞增多和全身症状的复杂性药物反应(DRESS)综合征病史。
Am J Case Rep. 2021 Feb 24;22:e927951. doi: 10.12659/AJCR.927951.
8
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome.药物反应伴嗜酸性粒细胞增多和全身症状(DRESS)综合征。
Clin Dermatol. 2020 Nov-Dec;38(6):702-711. doi: 10.1016/j.clindermatol.2020.06.008. Epub 2020 Jun 27.
9
Vancomycin-induced DRESS syndrome.万古霉素诱发的药物超敏反应伴嗜酸性粒细胞增多和系统症状综合征。
Ann Allergy Asthma Immunol. 2020 Jan;124(1):107-108. doi: 10.1016/j.anai.2019.09.002. Epub 2019 Sep 9.
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Representations of race and skin tone in medical textbook imagery.医学教材图像中的种族和肤色表现。
Soc Sci Med. 2018 Apr;202:38-42. doi: 10.1016/j.socscimed.2018.02.023. Epub 2018 Feb 23.