Iacobescu Loredana, Ciobanu Andreea-Olivia, Corlatescu Antonio-Daniel, Simionescu Maya, Iacobescu Georgian L, Dragomir Elena, Vinereanu Dragos
Cardiology, University of Medicine and Pharmacy "Carol Davila", Bucharest, ROU.
Cardiology, University Emergency Hospital, University of Medicine and Pharmacy "Carol Davila", Bucharest, ROU.
Cureus. 2024 Jul 8;16(7):e64100. doi: 10.7759/cureus.64100. eCollection 2024 Jul.
MicroRNAs, involved in a large variety of pathological conditions, tend to be potential specific biomarkers in cardiovascular diseases. Moreover, these short, non-coding RNAs, regulate post-transcriptional gene expression and protein synthesis, making them ideal for therapeutic targets. Down-regulation and up-regulation of specific microRNAs are currently studied as a novel approach to the diagnosis and treatment of cardiovascular diseases, such as chronic and acute coronary syndromes, atherosclerosis, heart failure, and arrhythmia. MicroRNAs are interesting and attractive targets for cardiovascular-associated therapeutics because of their stability, tissue-specific expression pattern, and secretion of body fluids. Extended research on their isolation, detection, and function will provide the standardization needed for using microRNAs as biomarkers and potential therapeutic targets. This review will summarize recent data on the implication of microRNAs in cardiovascular diseases, their potential role as biomarkers for diagnosis, and also the challenges of using microRNAs as future therapeutic targets.
微小RNA参与多种病理状况，往往是心血管疾病中潜在的特异性生物标志物。此外，这些短链非编码RNA可调节转录后基因表达和蛋白质合成，使其成为理想的治疗靶点。目前，特定微小RNA的下调和上调作为诊断和治疗心血管疾病（如慢性和急性冠状动脉综合征、动脉粥样硬化、心力衰竭和心律失常）的新方法正在研究中。微小RNA因其稳定性、组织特异性表达模式和体液分泌，成为心血管相关治疗的有趣且有吸引力的靶点。对其分离、检测和功能的深入研究将为把微小RNA用作生物标志物和潜在治疗靶点提供所需的标准化。本综述将总结关于微小RNA在心血管疾病中的作用、其作为诊断生物标志物的潜在作用以及将微小RNA用作未来治疗靶点所面临挑战的最新数据。
