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含曲马多和卡立普多的假冒及标签错误药品的不良反应。

Adverse effects from counterfeit and mislabeled medicine containing tapentadol and carisoprodol.

作者信息

Plæhn Gitte, Fuglsang Thomas, Hindersson Peter, Breindahl Torben

机构信息

KABS Stjernevang, Drug and Alcohol Rehabilitation Centre Copenhagen Denmark.

Department of Clinical Biochemistry North Denmark Regional Hospital Hjørring Denmark.

出版信息

Clin Case Rep. 2024 Aug 6;12(8):e9241. doi: 10.1002/ccr3.9241. eCollection 2024 Aug.

DOI:10.1002/ccr3.9241
PMID:39114837
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11303665/
Abstract

When self-administration with counterfeit or mislabeled medicine is suspected, comprehensive laboratory analysis should be preferred over immunoassay screening to avoid false negative results. Carisoprodol, which was formerly a popular muscle relaxant drug in many countries, has reappeared on illegal drug markets, and may cause an itching, purple-colored rash, even after a single dose.

摘要

当怀疑存在使用假冒或标签错误药品进行自我给药的情况时，应优先进行全面的实验室分析而非免疫分析筛查，以避免出现假阴性结果。卡立普多曾是许多国家常用的肌肉松弛药物，现已重新出现在非法药品市场上，即使单次服用也可能导致瘙痒、紫色皮疹。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8866/11303665/85b03c038daa/CCR3-12-e9241-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8866/11303665/85b03c038daa/CCR3-12-e9241-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8866/11303665/85b03c038daa/CCR3-12-e9241-g001.jpg

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PLOS Glob Public Health. 2024 Jan 18;4(1):e0002784. doi: 10.1371/journal.pgph.0002784. eCollection 2024.
2
Tapentadol dependence through intravenous injection ('shooting') of crushed tablets associated with cutaneous pseudoallergic reactions.通过静脉注射（“注射”）碾碎的片剂导致的曲马多依赖，伴有皮肤假性过敏反应。
BMJ Case Rep. 2023 Dec 19;16(12):e257721. doi: 10.1136/bcr-2023-257721.
3
Abuse of tapentadol compared to other atypical opioids among individuals entering treatment for opioid use disorders.
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J Opioid Manag. 2023 Sep-Oct;19(5):445-453. doi: 10.5055/jom.0818.
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Increased incidence of mixed drug toxicity deaths involving tapentadol - A forensic study.涉及他喷他多的混合药物毒性死亡事件发生率增加 - 一项法医学研究。
Med Sci Law. 2024 Apr;64(2):113-120. doi: 10.1177/00258024231183504. Epub 2023 Jun 23.
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Fentanyl, heroin, and methamphetamine-based counterfeit pills sold at tourist-oriented pharmacies in Mexico: An ethnographic and drug checking study.在墨西哥面向游客的药店出售的芬太尼、海洛因和冰毒为基础的假冒药丸：一项民族志和药物检测研究。
Drug Alcohol Depend. 2023 Aug 1;249:110819. doi: 10.1016/j.drugalcdep.2023.110819. Epub 2023 Jun 9.
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Pharmaceut Med. 2023 Jul;37(4):281-290. doi: 10.1007/s40290-023-00468-w. Epub 2023 May 15.
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Harm Reduct J. 2022 May 25;19(1):52. doi: 10.1186/s12954-022-00634-4.
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