Kyriakos Saad Melissa, El Hajj Imad, Saikaly Elias
Saint George Hospital University Medical Center Beirut Lebanon.
Department of General Surgery Saint George Hospital University Medical Center, Saint George University of Beirut Beirut Lebanon.
Clin Case Rep. 2024 Aug 6;12(8):e9283. doi: 10.1002/ccr3.9283. eCollection 2024 Aug.
Sarcoidosis is a systemic granulomatous disease with an unknown cause, marked by the presence of noncaseating granulomas in the affected organs. While the pulmonary interstitium is most frequently involved, the disease can affect almost any other organ system. Extrapulmonary involvement can occur with or without lung involvement, but isolated extrapulmonary involvement is a rare event. Isolated splenomegaly is very rare and presents an uncommon manifestation of sarcoidosis, its diagnoses is a challenge due to a broad differential diagnosis. Here, we present an intriguing case of a 28-year-old male with isolated splenic sarcoidosis.
Sarcoidosis is a systemic disease of unknown cause, marked by the presence of noncaseating granulomas in affected organs. It most frequently impacts the pulmonary interstitium, though it can also affect nearly any other organ system. This involvement can occur with or without lung involvement, but isolated extrapulmonary cases are observed in only about 10% of instances. Furthermore, isolated splenomegaly is an exceptionally rare event and an uncommon presentation of sarcoidosis, posing a significant clinical challenge due to the wide differential diagnosis. Potential differential diagnoses include hematologic cancers, primary or metastatic splenic tumors, infiltrative diseases, inflammatory conditions, and infections. We present a noteworthy case of a 28-year-old with isolated splenic sarcoidosis.
结节病是一种病因不明的全身性肉芽肿性疾病，其特征是在受影响器官中存在非干酪样肉芽肿。虽然肺间质最常受累，但该疾病几乎可影响任何其他器官系统。肺外受累可在有或无肺部受累的情况下发生，但孤立性肺外受累是罕见事件。孤立性脾肿大非常罕见，是结节病的一种不常见表现，由于鉴别诊断范围广泛，其诊断具有挑战性。在此，我们报告一例28岁男性孤立性脾脏结节病的有趣病例。
结节病是一种病因不明的全身性疾病，其特征是在受影响器官中存在非干酪样肉芽肿。它最常影响肺间质，不过也可影响几乎任何其他器官系统。这种受累可在有或无肺部受累的情况下发生，但仅约10%的病例为孤立性肺外病例。此外，孤立性脾肿大是一种极其罕见的事件，也是结节病的一种不常见表现，由于鉴别诊断范围广泛，构成重大临床挑战。潜在的鉴别诊断包括血液系统癌症、原发性或转移性脾脏肿瘤、浸润性疾病、炎症性疾病和感染。我们报告一例28岁孤立性脾脏结节病的值得关注的病例。
