Samuel Rajeen Karunakaran, Umakanth Maheswaran
Internal Medicine, Teaching Hospital Batticaloa, Batticaloa, LKA.
Clinical Medicine, Teaching Hospital Batticaloa, Batticaloa, LKA.
Cureus. 2022 Jan 7;14(1):e21020. doi: 10.7759/cureus.21020. eCollection 2022 Jan.
Sarcoidosis is a granulomatous disease with multiple system involvement. It is characterized by the presence of non-caseating granulomas in the involved organs. The most commonly affected organ in sarcoidosis is the pulmonary interstitium. However, extra-pulmonary involvement can be manifested in almost any other organ system. Less commonly, sarcoidosis can manifest with massive splenomegaly. As extensive differential diagnoses, such as hematological malignancies, primary splenic or metastatic tumors, infiltrative disorders, and inflammatory disorders are considered, diagnosing sarcoidosis with the presentation of massive splenomegaly is clinically challenging. Here, we discuss the case of a 56-year-old female with splenic sarcoidosis and skin manifestation.
结节病是一种累及多个系统的肉芽肿性疾病。其特征是受累器官中存在非干酪样肉芽肿。结节病最常受累的器官是肺间质。然而，肺外受累几乎可出现在任何其他器官系统。较少见的是，结节病可表现为巨脾。由于需要考虑广泛的鉴别诊断，如血液系统恶性肿瘤、原发性脾脏或转移性肿瘤、浸润性疾病和炎症性疾病，因此临床上诊断表现为巨脾的结节病具有挑战性。在此，我们讨论一例56岁女性脾脏结节病伴皮肤表现的病例。
