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Hydrazide-based reactive matrices for the sensitive detection of aldehydes and ketones by MALDI mass spectrometry imaging.

作者信息

Lodén Henrik, Schembri Luke S, Nilsson Anna, Kaya Ibrahim, Shariatgorji Reza, Odell Luke R, Andrén Per E

机构信息

Department of Pharmaceutical Biosciences, Spatial Mass Spectrometry, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.

出版信息

Chem Commun (Camb). 2024 Aug 22;60(69):9238-9241. doi: 10.1039/d4cc02475c.

DOI:10.1039/d4cc02475c
PMID:39114958
Abstract

A one-step, on-tissue chemical derivatisation method for MALDI mass spectrometry imaging was found to improve the detectability of aldehydes and ketones by charge-tagging. The developed reactive matrices, containing a UV-chromophore, ionisable moiety and hydrazide group, showed an equal or higher detection efficiency than Girard's reagent P, enabling improved imaging of brain metabolites without the need for additional co-matrices.

摘要

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