Wang Tian, Zhang Zengyu, Gao Fan, Yan Xiaoyu
Key Laboratory of Advanced Light Conversion Materials and Biophotonics, School of Chemistry and Life Resources, Renmin University of China, Beijing 100872, China.
Org Lett. 2024 Aug 16;26(32):6915-6920. doi: 10.1021/acs.orglett.4c02576. Epub 2024 Aug 8.
Ketones, as essential functional group skeletons, have garnered significant interest due to their diverse transformations. Herein, we describe a versatile photoredox catalyzed deacylation-aroylation strategy that enables the direct transformation of alkyl ketones to aryl ketones. This process involves photoredox deacylation of dihydroquinazolinones derived from alkyl ketones to generate alkyl radicals, followed by subsequent NHC-catalyzed or NHC-mediated radical aroylation.
酮作为重要的官能团骨架，因其多样的转化反应而备受关注。在此，我们描述了一种通用的光氧化还原催化脱酰基-芳酰化策略，该策略能够将烷基酮直接转化为芳基酮。这个过程包括对源自烷基酮的二氢喹唑啉酮进行光氧化还原脱酰基反应以生成烷基自由基，随后进行氮杂环卡宾催化或氮杂环卡宾介导的自由基芳酰化反应。
