掌跖脓疱病患者的健康相关生活质量——一项瑞典登记研究
Health-related quality of life in patients with palmoplantar pustulosis - a Swedish register study.
作者信息
Norlin Jenny M, Löfvendahl Sofia, Schmitt-Egenolf Marcus
机构信息
The Swedish Institute for Health Economics (IHE), Lund, Sweden.
Department of Laboratory Medicine, Lund University, Lund, Sweden.
出版信息
Ann Med. 2024 Dec;56(1):2386524. doi: 10.1080/07853890.2024.2386524. Epub 2024 Aug 8.
BACKGROUND
Real-world data on health-related quality of life (HRQoL) in palmoplantar pustulosis (PPP) are scarce and few studies have analysed the generic HRQoL.
OBJECTIVES
To assess HRQoL using the generic EQ-5D instrument and the Dermatology Life Quality Index (DLQI) instrument in PPP compared to plaque psoriasis.
METHODS
Cross-sectional data from PsoReg, the Swedish National Registry for Systemic Treatment of Psoriasis (2006-2021), were examined. The study included 306 patients with PPP, out of which 22% had concomitant plaque psoriasis ( = 68), and 7041 patients with plaque psoriasis only. EQ-5D and DLQI were compared between patients with PPP and patients with plaque psoriasis, overall and stratified by sex. A subgroup analysis compared outcomes for patients with PPP vs. patients with severe plaque psoriasis (Psoriasis Area and Severity Index ≥10). Multiple regression analyses were performed to control for potential confounders (age, sex, comorbidities, lifestyle factors).
RESULTS
Patients with PPP were to a larger extent female (79% vs. 37%, < .01) and older (mean [SD] age 59.9 [11.9] vs. 50.7 [16.0] years, < .01) than patients with plaque psoriasis. EQ-5D values were significantly lower (worse) in patients with PPP (mean [SD] 0.622 [0.309]) compared to patients with plaque psoriasis (mean [SD] 0.715 [0.274]). No significant difference was observed compared to patients with severe plaque psoriasis ( = .237). DLQI was comparable in PPP and plaque psoriasis patients ( = .117). In the regression analyses, PPP only and PPP with plaque psoriasis were associated with lower EQ-5D values of 0.065 ( < .01) and 0.061 points ( < .10) compared to plaque psoriasis patients.
CONCLUSIONS
PPP had a substantial negative impact on patients' generic and dermatology-specific HRQoL. Patients with PPP were worse off in terms of generic HRQoL compared with patients with plaque psoriasis when controlling for the impact of potential confounders.
背景
掌跖脓疱病（PPP）患者健康相关生活质量（HRQoL）的真实世界数据匮乏，且很少有研究分析其一般健康相关生活质量。
目的
使用一般健康状况问卷EQ-5D和皮肤病生活质量指数（DLQI）评估PPP患者与斑块状银屑病患者的健康相关生活质量。
方法
研究分析了瑞典国家银屑病系统治疗登记处（PsoReg，2006 - 2021年）的横断面数据。该研究纳入了306例PPP患者，其中22%（n = 68）合并斑块状银屑病，以及7041例仅患有斑块状银屑病的患者。比较了PPP患者与斑块状银屑病患者的EQ-5D和DLQI，总体比较以及按性别分层比较。亚组分析比较了PPP患者与重度斑块状银屑病患者（银屑病面积和严重程度指数≥10）的结果。进行了多元回归分析以控制潜在混杂因素（年龄、性别、合并症、生活方式因素）。
结果
与斑块状银屑病患者相比，PPP患者女性比例更高（79%对37%，P <.01）且年龄更大（平均[标准差]年龄59.9 [11.9]岁对50.7 [16.0]岁，P <.01）。PPP患者的EQ-5D值显著更低（更差）（平均[标准差]0.622 [0.309]），而斑块状银屑病患者为（平均[标准差]0.715 [0.274]）。与重度斑块状银屑病患者相比，未观察到显著差异（P =.237）。PPP患者和斑块状银屑病患者的DLQI相当（P =.117）。在回归分析中，与斑块状银屑病患者相比，仅患有PPP的患者以及合并斑块状银屑病的PPP患者的EQ-5D值分别降低0.065（P <.01）和0.061分（P <.10）。
结论
PPP对患者的一般健康相关生活质量和皮肤病特异性健康相关生活质量有重大负面影响。在控制潜在混杂因素的影响后，PPP患者在一般健康相关生活质量方面比斑块状银屑病患者更差。
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