Hepatitis Research Center, National Taiwan University College of Medicine and, National Taiwan University Hospital, Taipei, Taiwan.
Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan.
Hepatol Int. 2024 Oct;18(Suppl 2):897-908. doi: 10.1007/s12072-024-10699-x. Epub 2024 Aug 8.
Metabolic dysfunction-associated fatty liver disease (MAFLD) and viral hepatitis due to chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection are common liver diseases worldwide. Excessive alcohol consumption and alcoholic liver disease (ALD) are also emerging health problems. Therefore, in clinical practice, we may encounter subjects with dual etiology of liver diseases such as coexisting MAFLD/HBV, MAFLD/HCV, and MAFLD/ALD. In this review, we summarize the epidemiology, clinical features, and mutual interactions of MAFLD with coexisting HBV, HCV, or ALD. The impact of MAFLD on the progression of liver diseases and treatment outcomes in patients with chronic viral hepatitis and the clinical questions to be addressed regarding dual MAFLD and ALD are also discussed.
代谢相关脂肪性肝病（MAFLD）和由慢性乙型肝炎病毒（HBV）或丙型肝炎病毒（HCV）感染引起的病毒性肝炎是全球常见的肝脏疾病。过量饮酒和酒精性肝病（ALD）也是新出现的健康问题。因此，在临床实践中，我们可能会遇到同时存在两种病因的肝病患者，例如 MAFLD/HBV、MAFLD/HCV 和 MAFLD/ALD 并存。在这篇综述中，我们总结了 MAFLD 与同时存在的 HBV、HCV 或 ALD 的流行病学、临床特征和相互作用。MAFLD 对慢性病毒性肝炎患者肝病进展和治疗结局的影响，以及关于双重 MAFLD 和 ALD 的临床问题也进行了讨论。
