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[减重手术中的性别差异:流行病学、治疗与结果]

[Gender-specific differences in bariatric surgery: epidemiology, treatment and results].

作者信息

Téoule Patrick, Pozek Ema, Hielscher Thomas, Reißfelder Christoph, Stier Christine, Otto Mirko, Schölch Sebastian

机构信息

Chirurgische Klinik, Universitätsmedizin Mannheim, Medizinische Fakultät Mannheim, Ruprecht-Karls-Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Heidelberg, Deutschland.

Abteilung für Biostatistik (C060), Deutsches Krebsforschungszentrum, Heidelberg, Deutschland.

出版信息

Chirurgie (Heidelb). 2024 Sep;95(9):721-729. doi: 10.1007/s00104-024-02149-z. Epub 2024 Aug 8.

DOI:10.1007/s00104-024-02149-z
PMID:39115681
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11333528/
Abstract

This study investigates gender-specific differences in obesity and the treatment by metabolic bariatric surgery (MBS). The database includes 2393 patients (1725 women, 668 men) from for a high-volume center for bariatric surgery. Demographic, perioperative and follow-up data were retrospectively analyzed. Men had a significantly higher body mass index (BMI) and more frequent obesity-associated diseases. Despite the higher prevalence of obesity in men, women accounted for 80% of the surgical patients. On average men had longer operation times but with the same complication rates. Postoperatively, both sexes experienced a significant reduction in excess body weight, which was slightly more pronounced in women. The study particularly emphasizes the need to better motivate men to undergo obesity treatment in order to reduce the health consequences of morbid obesity in this population group.

摘要

本研究调查了肥胖症以及代谢减重手术(MBS)治疗方面的性别差异。该数据库包含来自一家大型减重手术中心的2393名患者(1725名女性,668名男性)。对人口统计学、围手术期和随访数据进行了回顾性分析。男性的体重指数(BMI)显著更高,且肥胖相关疾病更为常见。尽管男性肥胖患病率更高,但手术患者中女性占80%。平均而言,男性的手术时间更长,但并发症发生率相同。术后,两性的超重均显著减轻,女性的减轻程度略更明显。该研究特别强调需要更好地激励男性接受肥胖症治疗,以减少这一人群中病态肥胖对健康造成的后果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c2d/11333528/8155153cb0c4/104_2024_2149_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c2d/11333528/4c9b34a581d4/104_2024_2149_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c2d/11333528/4b07c52a0b5f/104_2024_2149_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c2d/11333528/8155153cb0c4/104_2024_2149_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c2d/11333528/4c9b34a581d4/104_2024_2149_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c2d/11333528/4b07c52a0b5f/104_2024_2149_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c2d/11333528/8155153cb0c4/104_2024_2149_Fig3_HTML.jpg

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本文引用的文献

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Sex, race, and BMI in clinical trials of medications for obesity over the past three decades: a systematic review.过去三十年来,肥胖药物临床试验中的性别、种族和 BMI:系统评价。
Lancet Diabetes Endocrinol. 2024 Jun;12(6):414-421. doi: 10.1016/S2213-8587(24)00098-6. Epub 2024 May 6.
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Metabolic Bariatric Surgery Across the IFSO Chapters: Key Insights on the Baseline Patient Demographics, Procedure Types, and Mortality from the Eighth IFSO Global Registry Report.IFSO 各章节的代谢减重手术:第八届 IFSO 全球注册研究报告中基线患者人口统计学特征、手术类型和死亡率的关键见解。
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Life Expectancy after Bariatric Surgery in the Swedish Obese Subjects Study.瑞典肥胖受试者研究中减肥手术后的预期寿命。
N Engl J Med. 2020 Oct 15;383(16):1535-1543. doi: 10.1056/NEJMoa2002449.
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Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery.瑞典肥胖受试者(SOS)试验的关键结果回顾-减肥手术的前瞻性对照干预研究。
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