Zeng Suling, Schnabl Bernd
Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, China.
Department of Medicine, University of California San Diego, La Jolla, California, United States of America.
PLoS Pathog. 2024 Aug 8;20(8):e1012377. doi: 10.1371/journal.ppat.1012377. eCollection 2024 Aug.
Chronic liver disease and its complications are a significant global health burden. Changes in fungal communities (mycobiome), an integral component of the gut microbiome, are associated with and contribute to the development of liver disease. Fungal dysbiosis can induce intestinal barrier dysfunction and allow fungal products to translocate to the liver causing progression of disease. This review explores recent progress in understanding the compositional and functional diversity of gut mycobiome signatures across different liver diseases. It delves into causative connections between gut fungi and liver diseases. We emphasize the significance of fungal translocation, with a particular focus on fungal-derived metabolites and immune cells induced by fungi, as key contributors to liver disease. Furthermore, we review the potential impact of the intrahepatic mycobiome on the progression of liver diseases.
慢性肝病及其并发症是一项重大的全球健康负担。真菌群落（真菌微生物组）作为肠道微生物组的一个组成部分，其变化与肝病的发生相关并起到促进作用。真菌生态失调可导致肠道屏障功能障碍，并使真菌产物转移至肝脏，从而促使疾病进展。本综述探讨了在理解不同肝病中肠道真菌微生物组特征的组成和功能多样性方面的最新进展。它深入研究了肠道真菌与肝病之间的因果联系。我们强调真菌易位的重要性，特别关注真菌衍生的代谢产物和由真菌诱导的免疫细胞，它们是肝病的关键促成因素。此外，我们还综述了肝内真菌微生物组对肝病进展的潜在影响。
