Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Leiden University Medical Center, 2300 RC Leiden, Netherlands.
Science. 2024 Aug 9;385(6709):667-671. doi: 10.1126/science.adn4614. Epub 2024 Aug 8.
The short-term impact of famines on death and disease is well documented, but estimating their potential long-term impact is difficult. We used the setting of the man-made Ukrainian Holodomor famine of 1932-1933 to examine the relation between prenatal famine and adult type 2 diabetes mellitus (T2DM). This ecological study included 128,225 T2DM cases diagnosed from 2000 to 2008 among 10,186,016 male and female Ukrainians born from 1930 to 1938. Individuals who were born in the first half-year of 1934, and hence exposed in early gestation to the mid-1933 peak famine period, had a greater than twofold likelihood of T2DM compared with that of unexposed controls. There was a dose-response relationship between severity of famine exposure and increase in adult T2DM risk.
饥荒对死亡和疾病的短期影响已有充分记录，但估计其潜在的长期影响却很困难。我们利用人为的 1932-1933 年乌克兰大饥荒来研究产前饥荒与成人 2 型糖尿病（T2DM）之间的关系。这项生态研究包括在 2000 年至 2008 年期间诊断出的 1018.6016 名出生于 1930 年至 1938 年的男性和女性乌克兰人中的 128225 例 T2DM 病例。那些在 1934 年上半年出生的人，因此在早期妊娠中暴露于 1933 年中期的饥荒高峰期，与未暴露的对照组相比，T2DM 的可能性要高出两倍以上。饥荒暴露的严重程度与成人 T2DM 风险的增加之间存在剂量反应关系。
