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上皮-间充质转化相关评分函数可作为预测胶质瘤免疫治疗和候选药物的工具。

Epithelial-Mesenchymal Transition Related Score Functions as a Predictive Tool for Immunotherapy and Candidate Drugs in Glioma.

机构信息

Sanbo Brain Hospital, Capital Medical University No. 50, Yikesong Road, Xiangshan, Haidian District, Beijing 100070, China.

Laboratory for Clinical Medicine, Capital Medical University, No. 10, You'anmenwai, Fengtai District, Beijing 100070, China.

出版信息

J Chem Inf Model. 2024 Aug 26;64(16):6648-6661. doi: 10.1021/acs.jcim.4c00620. Epub 2024 Aug 8.

DOI:10.1021/acs.jcim.4c00620
PMID:39116318
Abstract

Gliomas are aggressive CNS tumors where the epithelial-mesenchymal transition (EMT) is crucial for prognosis. We developed an EMT-based score predicting overall survival (OS) and conducted pathway analyses, revealing functions such as cell proliferation and immune response in glioma progression. The EMT score, correlated with immune functions and cell infiltration, shows potential as an immune response indicator. We identified two promising compounds, BIX02189 and QL-XI-92, as potential glioma treatments based on candidate gene analysis.

摘要

神经胶质瘤是一种侵袭性中枢神经系统肿瘤，上皮-间充质转化（EMT）对预后至关重要。我们开发了一种基于 EMT 的评分系统来预测总生存期（OS），并进行了通路分析，揭示了 EMT 在神经胶质瘤进展中的作用，如细胞增殖和免疫反应。EMT 评分与免疫功能和细胞浸润相关，具有作为免疫反应指标的潜力。我们通过候选基因分析，确定了两种有前途的化合物 BIX02189 和 QL-XI-92，作为潜在的神经胶质瘤治疗药物。

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