针对癌症干细胞中的上皮-间充质转化，以改善脑胶质瘤的临床预后。
Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma.
机构信息
The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
*Both authors contributed equally to this study and share first authorship.
出版信息
Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820948053. doi: 10.1177/1533033820948053.
Abstract
Glioma is one of the most common malignant tumors of the central nervous system with a poor prognosis at present due to lack of effective treatment options. Its initiation, migration, and multipotency are affected by cancer stem cell's transition. Previous studies imply that changes in the cancer stem cells can affect the malignant differentiation of the tumor. We found that the epithelial-to-mesenchymal transition (EMT)-related regulatory pathway is an important target for tumor therapy. In this review, we discuss the transition factor of EMT and 3 specific pathways that affect the EMT of cancer stem cells during tumor development. We conclude that targeting the EMT process of cancer stem cells can be a feasible approach in the treatment of glioma.
摘要
脑胶质瘤是中枢神经系统最常见的恶性肿瘤之一，目前由于缺乏有效的治疗方法，预后较差。其发生、迁移和多能性受癌症干细胞转化的影响。先前的研究表明，癌症干细胞的变化会影响肿瘤的恶性分化。我们发现上皮-间充质转化（EMT）相关调控途径是肿瘤治疗的重要靶点。在这篇综述中，我们讨论了 EMT 的转化因子以及在肿瘤发展过程中影响癌症干细胞 EMT 的 3 条特定途径。我们得出结论，针对癌症干细胞的 EMT 过程可能是治疗脑胶质瘤的一种可行方法。
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本文引用的文献
1
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2
Tumor microenvironment participates in metastasis of pancreatic cancer.肿瘤微环境参与胰腺癌转移。
Mol Cancer. 2018 Jul 30;17(1):108. doi: 10.1186/s12943-018-0858-1.
3
A drug combination targeting hypoxia induced chemoresistance and stemness in glioma cells.一种针对胶质瘤细胞中缺氧诱导的化疗耐药性和干性的联合药物。
Oncotarget. 2018 Apr 6;9(26):18351-18366. doi: 10.18632/oncotarget.24839.
4
Targeting Cyclin D-CDK4/6 Sensitizes Immune-Refractory Cancer by Blocking the SCP3-NANOG Axis.靶向细胞周期蛋白 D-CDK4/6 通过阻断 SCP3-NANOG 轴使免疫难治性癌症敏感化。
Cancer Res. 2018 May 15;78(10):2638-2653. doi: 10.1158/0008-5472.CAN-17-2325. Epub 2018 Feb 6.
5
EMT in cancer.肿瘤中的 EMT。
Nat Rev Cancer. 2018 Feb;18(2):128-134. doi: 10.1038/nrc.2017.118. Epub 2018 Jan 12.
6
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