The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
*Both authors contributed equally to this study and share first authorship.
Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820948053. doi: 10.1177/1533033820948053.
Glioma is one of the most common malignant tumors of the central nervous system with a poor prognosis at present due to lack of effective treatment options. Its initiation, migration, and multipotency are affected by cancer stem cell's transition. Previous studies imply that changes in the cancer stem cells can affect the malignant differentiation of the tumor. We found that the epithelial-to-mesenchymal transition (EMT)-related regulatory pathway is an important target for tumor therapy. In this review, we discuss the transition factor of EMT and 3 specific pathways that affect the EMT of cancer stem cells during tumor development. We conclude that targeting the EMT process of cancer stem cells can be a feasible approach in the treatment of glioma.
脑胶质瘤是中枢神经系统最常见的恶性肿瘤之一，目前由于缺乏有效的治疗方法，预后较差。其发生、迁移和多能性受癌症干细胞转化的影响。先前的研究表明，癌症干细胞的变化会影响肿瘤的恶性分化。我们发现上皮-间充质转化（EMT）相关调控途径是肿瘤治疗的重要靶点。在这篇综述中，我们讨论了 EMT 的转化因子以及在肿瘤发展过程中影响癌症干细胞 EMT 的 3 条特定途径。我们得出结论，针对癌症干细胞的 EMT 过程可能是治疗脑胶质瘤的一种可行方法。
