丁香脂素 D-F，从紫丁香中分离得到的新丁香脂素及其对 BV 细胞的抗炎作用。
Noralashinols D-F, New Norlignans from Syringa pinnatifolia and its Anti-Inflammation in BV Cells.
机构信息
Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102448, P. R. China.
College of Pharmacy, Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010110, P. R. China.
出版信息
Chem Biodivers. 2024 Nov;21(11):e202401567. doi: 10.1002/cbdv.202401567. Epub 2024 Oct 3.
Four new norlignans, noralashinols D-F (1a/b-3), and two known analogues (4 and 5) were isolated from the peeled stems of Syringa pinnatifolia Hemsl. The structures were elucidated by analysis of spectroscopic data, such as IR, HR-ESI-MS, 1D and 2D NMR, and ECD. All compounds were evaluated for anti-inflammatory activities against NO production induced by LPS in BV microglia cells. Compounds 1b and 2 exhibited moderate activities with IC values of 32.39±9.1 and 47.83±10.44 μM, respectively, compared with positive control indomethacin (IC=21.62 μM). It is worth to note that 1, 3, and 4 have a distinctive woody fragrance.
从丁香属植物的去皮茎中分离得到了四个新的木脂素，即 noralashinols D-F（1a/b-3），以及两个已知的类似物（4 和 5）。通过分析光谱数据，如 IR、HR-ESI-MS、1D 和 2D NMR 以及 ECD，确定了它们的结构。所有化合物均针对 LPS 诱导的 BV 小胶质细胞中 NO 产生的抗炎活性进行了评估。与阳性对照吲哚美辛（IC=21.62 μM）相比，化合物 1b 和 2 表现出中等活性，IC 值分别为 32.39±9.1 和 47.83±10.44 μM。值得注意的是，1、3 和 4 具有独特的木质香气。
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