细胞因子风暴综合征的实验室特征和病理学。
Laboratory Features and Pathology of Cytokine Storm Syndromes.
机构信息
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
出版信息
Adv Exp Med Biol. 2024;1448:43-58. doi: 10.1007/978-3-031-59815-9_5.
The laboratory diagnosis of cytokine storm syndromes (CSSs), i.e., hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS), is often challenging. The laboratory features using routinely available tests lack specificity, whereas confirmatory testing is available in only few laboratories in the United States. The disease mechanisms are still largely unclear, particularly in adults. In this chapter, the pathogenesis of CSSs, their associated laboratory findings, and recommended diagnostic strategies are reviewed.
细胞因子风暴综合征（CSSs），即噬血细胞性淋巴组织细胞增生症（HLH）和巨噬细胞活化综合征（MAS）的实验室诊断常常具有挑战性。常规检测的实验室特征缺乏特异性，而在美国仅有少数实验室可提供确证性检测。其发病机制在很大程度上仍不清楚，尤其是在成人中。本章回顾了 CSSs 的发病机制、相关实验室发现以及推荐的诊断策略。
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