Soleimani-Amiri Somayeh, Hojjati Mahsa, Hossaini Zinatossadat
Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran.
Department of Natural Sciences, School of Science and Technology, The University of Georgia, 0171, Tbilisi, Georgia.
Mol Divers. 2025 Apr;29(2):1493-1506. doi: 10.1007/s11030-024-10929-2. Epub 2024 Aug 8.
A multicomponent synthesis of 1,8-naphthyridine with high yields utilizing benzaldehydes, malononitrile, phenol, and acetylenic esters in aqueous solution at room temperature in the presence of SiO/FeO as a reusable catalyst is reported. Using the MTT test, the cytotoxic properties of all the produced compounds were assessed in vitro against cancer cell lines (MCF-7 and A549) and normal cell lines (BEAS-2B). It was discovered that the most effective cytotoxic agent, doxorubicin-like in its lack of selectivity, was the derivative 5h. On the other hand, the compound 5c might be regarded as an equipotent molecule with greater selectivity in relation to doxorubicin. Also, this study investigates the antioxidant effects of 1,8-naphthyridine carboxylates, along with other studies conducted in this study.
报道了一种在室温下的水溶液中，以SiO/FeO作为可重复使用的催化剂，利用苯甲醛、丙二腈、苯酚和炔酸酯高产率多组分合成1,8-萘啶的方法。使用MTT试验，在体外评估了所有生成化合物对癌细胞系（MCF-7和A549）和正常细胞系（BEAS-2B）的细胞毒性。发现最有效的细胞毒性剂是衍生物5h，其缺乏选择性，类似于阿霉素。另一方面，化合物5c可能被视为一种与阿霉素相比具有更高选择性的等效分子。此外，本研究还考察了1,8-萘啶羧酸盐的抗氧化作用，以及本研究中进行的其他研究。
