• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

TAF15 Overexpression Impairs Memory in Mice by Inhibiting the Transcription of Npas4.

作者信息

Ding Meijie, Li Dingfeng, Zhang Juan, Liu Qiang

机构信息

Department of Neurology, The First Affiliated Hospital of USTC, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, 230001, China.

Neurodegenerative Disorder Research Center, Anhui Province Key Laboratory of Biomedical Aging Research, University of Science and Technology of China, Hefei, 230027, China.

出版信息

Neurosci Bull. 2024 Dec;40(12):1937-1942. doi: 10.1007/s12264-024-01273-4. Epub 2024 Aug 8.

DOI:10.1007/s12264-024-01273-4
PMID:39117935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11625027/
Abstract
摘要

相似文献

1
TAF15 Overexpression Impairs Memory in Mice by Inhibiting the Transcription of Npas4.TAF15过表达通过抑制Npas4的转录损害小鼠记忆。
Neurosci Bull. 2024 Dec;40(12):1937-1942. doi: 10.1007/s12264-024-01273-4. Epub 2024 Aug 8.
2
The intrinsic excitability of and autophagy protein expression levels in dentate gyrus ensembles regulate fear generalization.齿状回神经元集群的内在兴奋性和自噬蛋白表达水平调节恐惧泛化。
Neural Regen Res. 2025 Jun 19. doi: 10.4103/NRR.NRR-D-24-01026.
3
Inhibition of HDAC3 induces neuroprotection by activating the Npas4 signaling pathway following surgical brain injury in rats.抑制HDAC3通过激活大鼠脑损伤手术后的Npas4信号通路诱导神经保护作用。
Iran J Basic Med Sci. 2025;28(8):1004-1011. doi: 10.22038/ijbms.2025.80235.17372.
4
Combinative protein expression of immediate early genes c-Fos, Arc, and Npas4 along aversive- and reward-related neural networks.即刻早期基因c-Fos、Arc和Npas4在厌恶相关和奖赏相关神经网络中的联合蛋白表达。
bioRxiv. 2025 May 22:2025.04.21.649441. doi: 10.1101/2025.04.21.649441.
5
Transcription Factor EB Overexpression through Glial Fibrillary Acidic Protein Promoter Disrupts Neuronal Lamination by Dysregulating Neurogenesis during Embryonic Development.通过胶质纤维酸性蛋白启动子过表达转录因子EB会在胚胎发育过程中通过失调神经发生来破坏神经元分层。
Dev Neurosci. 2025;47(1):40-54. doi: 10.1159/000538656. Epub 2024 Apr 18.
6
Experience-induced NPAS4 reduces dendritic inhibition from CCK+ inhibitory neurons and enhances plasticity.经验诱导的NPAS4减少了来自CCK+抑制性神经元的树突抑制并增强了可塑性。
J Neurophysiol. 2025 Jul 1;134(1):361-371. doi: 10.1152/jn.00216.2025. Epub 2025 Jun 30.
7
SMARCC2 mediates the regulation of DKK1 by the transcription factor EGR1 through chromatin remodeling to reduce the proliferative capacity of glioblastoma.SMARCC2 通过染色质重塑介导转录因子 EGR1 对 DKK1 的调控，从而降低神经胶质瘤的增殖能力。
Cell Death Dis. 2022 Nov 23;13(11):990. doi: 10.1038/s41419-022-05439-8.
8
Npas4 impairs fear memory via phosphorylated HDAC5 induced by CGRP administration in mice.Npas4 通过 CGRP 给药诱导的磷酸化 HDAC5 损害小鼠的恐惧记忆。
Sci Rep. 2021 Mar 26;11(1):7006. doi: 10.1038/s41598-021-86556-w.
9
Overexpression of PBX1 attenuates oxidative stress and apoptosis in diabetic cardiomyopathy by transcriptionally inhibiting TXNIP.PBX1的过表达通过转录抑制TXNIP减轻糖尿病心肌病中的氧化应激和细胞凋亡。
Int J Biochem Cell Biol. 2025 Sep;186:106828. doi: 10.1016/j.biocel.2025.106828. Epub 2025 Jul 3.
10
The neuronal PAS domain protein 4 (Npas4) is required for new and reactivated fear memories.神经元 PAS 结构域蛋白 4（Npas4）对于新的和重新激活的恐惧记忆是必需的。
PLoS One. 2011;6(8):e23760. doi: 10.1371/journal.pone.0023760. Epub 2011 Aug 22.

引用本文的文献

1
SFRS8 Regulates Memory by Modulating RNA Splicing of Synaptic Genes.SFRS8通过调节突触基因的RNA剪接来调控记忆。
Mol Neurobiol. 2025 May 26. doi: 10.1007/s12035-025-05036-8.

本文引用的文献

1
Mechanisms Underlying Brain Aging Under Normal and Pathological Conditions.正常和病理条件下大脑老化的潜在机制。
Neurosci Bull. 2023 Feb;39(2):303-314. doi: 10.1007/s12264-022-00969-9. Epub 2022 Nov 27.
2
TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.TIF1γ 通过与 TAF15/TBP 复合物相互作用抑制肺腺癌 EMT 和转移。
Cell Rep. 2022 Oct 18;41(3):111513. doi: 10.1016/j.celrep.2022.111513.
3
The atypical RNA-binding protein Taf15 regulates dorsoanterior neural development through diverse mechanisms in Xenopus tropicalis.非典型 RNA 结合蛋白 Taf15 通过多种机制在非洲爪蟾中调控背侧前脑神经发育。
Development. 2021 Aug 1;148(15). doi: 10.1242/dev.191619. Epub 2021 Aug 4.
4
Correction to: LncRNA GAS5 activates the HIF1A/VEGF pathway by binding to TAF15 to promote wound healing in diabetic foot ulcers.对以下内容的修正：长链非编码RNA GAS5通过与TAF15结合激活HIF1A/VEGF通路以促进糖尿病足溃疡的伤口愈合
Lab Invest. 2021 Aug;101(8):1111. doi: 10.1038/s41374-021-00603-8.
5
USF1-induced upregulation of LINC01048 promotes cell proliferation and apoptosis in cutaneous squamous cell carcinoma by binding to TAF15 to transcriptionally activate YAP1.USF1 诱导的 LINC01048 上调通过与 TAF15 结合促进转录激活 YAP1 促进皮肤鳞状细胞癌中的细胞增殖和凋亡。
Cell Death Dis. 2019 Apr 1;10(4):296. doi: 10.1038/s41419-019-1516-2.
6
The effects of aging in the hippocampus and cognitive decline.衰老对海马体的影响及认知衰退
Neurosci Biobehav Rev. 2017 Aug;79:66-86. doi: 10.1016/j.neubiorev.2017.04.030. Epub 2017 May 2.
7
NPTX2 and cognitive dysfunction in Alzheimer's Disease.NPTX2与阿尔茨海默病中的认知功能障碍
Elife. 2017 Mar 23;6:e23798. doi: 10.7554/eLife.23798.
8
Histone Deacetylase 2 Inhibition Attenuates Downregulation of Hippocampal Plasticity Gene Expression during Aging.组蛋白去乙酰化酶 2 抑制可减轻衰老过程中海马可塑性基因表达的下调。
Mol Neurobiol. 2018 Mar;55(3):2432-2442. doi: 10.1007/s12035-017-0490-x. Epub 2017 Mar 31.
9
Quantitative protein profiling of hippocampus during human aging.人类衰老过程中海马体的蛋白质定量分析。
Neurobiol Aging. 2016 Mar;39:46-56. doi: 10.1016/j.neurobiolaging.2015.11.029. Epub 2015 Dec 8.
10
Biochemical Properties and Biological Functions of FET Proteins.FET蛋白的生化特性与生物学功能
Annu Rev Biochem. 2015;84:355-79. doi: 10.1146/annurev-biochem-060614-034325. Epub 2014 Dec 8.