Department of Chemistry, Faculty of Science and Engineering-Universitas Nusa Cendana, Jln Adi Sucipto Penfui, Kupang, NTT, Indonesia.
Laboratorium Terpadu (Biosains), Universitas Nusa Cendana, Jln. Adi Sucipto Penfui, Kupang, NTT, Indonesia.
J Antibiot (Tokyo). 2024 Nov;77(11):778-782. doi: 10.1038/s41429-024-00764-w. Epub 2024 Aug 8.
Most of the natural products containing tetramic acid have trans configuration of the decalin moiety. Undana A (1), a new cis decalin-bearing tetramic acid metabolite was isolated from endophytic fungi Nigrospora oryzae associated with Avicennia marina. The structure was determined based on the mass and NMR spectral data together with the comparison of the literature. This is the first report of cis decalin-tetramic acid metabolite from the mangrove endophytic fungus. Compound 1 was tested for cytotoxic against L5178Y mouse cancer cells and antibacterial activity against several gram-positive including MRSA and gram-negative bacteria but was found inactive.
大多数含有四氢酸的天然产物中，十氢萘部分具有反式构型。从与红树林植物海桑相关的内生真菌稻曲黑粉菌中分离到一种新的顺式十氢萘四氢酸代谢物，命名为 Undana A（1）。结构根据质谱和 NMR 谱数据以及文献比较确定。这是首次从红树林内生真菌中报道顺式十氢萘四氢酸代谢物。对 L5178Y 小鼠癌细胞进行细胞毒性测试和对包括 MRSA 在内的几种革兰氏阳性菌和革兰氏阴性菌进行抗菌活性测试，发现化合物 1 没有活性。
