Li Kaiqi, Xiao Xiangyu, Li Yuling, Lu Sichen, Zi Jianghang, Sun Xiaoqiang, Xu Jia, Liu Hao-Yu, Li Xiaoqiong, Song Tongxing, Cai Demin
Laboratory of Animal Physiology and Molecular Nutrition, Jiangsu Key Laboratory of Animal Genetic Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
J Anim Sci Biotechnol. 2024 Aug 8;15(1):114. doi: 10.1186/s40104-024-01073-w.
Obesity is a prevalent chronic disease that has significant negative impacts on humans and our companion animals, including dogs and cats. Obesity occurs with multiple comorbidities, such as diabetes, hypertension, heart disease and osteoarthritis in dogs and cats. A direct link between lipid metabolism dysregulation and obesity-associated diseases has been implicated. However, the understanding of such pathophysiology in companion animals is limited. This review aims to address the role of lipid metabolism in various metabolic disorders associated with obesity, emphasizing the involvement of the gut microbiota. Furthermore, we also discuss the management of obesity, including approaches like nutritional interventions, thus providing novel insights into obesity prevention and treatment for canines and felines.
肥胖是一种普遍存在的慢性疾病，对人类以及我们的伴侣动物，包括狗和猫，都有重大负面影响。肥胖常伴有多种合并症，如犬猫的糖尿病、高血压、心脏病和骨关节炎。脂质代谢失调与肥胖相关疾病之间的直接联系已被证实。然而，对伴侣动物这种病理生理学的了解有限。本综述旨在探讨脂质代谢在与肥胖相关的各种代谢紊乱中的作用，强调肠道微生物群的参与。此外，我们还讨论了肥胖的管理，包括营养干预等方法，从而为犬猫肥胖的预防和治疗提供新的见解。
