McQuire Cheryl, Frennesson Nessie Felicia, Parsonage James, Van der Heiden Molly, Troy David, Zuccolo Luisa
Bristol Medical School, University of Bristol, Bristol, UK.
Tobacco and Alcohol Research Group, School of Psychological Science, University of Bristol, Bristol, UK.
Alcohol Clin Exp Res (Hoboken). 2024 Oct;48(10):1819-1833. doi: 10.1111/acer.15415. Epub 2024 Aug 8.
Fetal alcohol spectrum disorder (FASD) is a leading cause of neurodevelopmental disability globally. International organizations have highlighted an urgent need for improved prevention, diagnosis, and support. However, the evidence base needed to inform this is thought to be limited. We conducted two complementary reviews to (i) describe trends in the volume and characteristics of original FASD research articles (Review 1) and (ii) compare the volume of published research on FASD to that of other neurodevelopmental disorders (Review 2). In Review 1, we systematically searched MEDLINE, Embase, CINAHL and PsycInfo for original studies with FASD terms in the title, published between 2000 and 2023. We summarised study characteristics including the article topic(s), sample population, country of origin, and publication year using quantitative content analysis and time-series plots. A total of 854 studies were eligible. Studies showed a relative focus on diagnosis and screening, compared to prevention and intervention. FASD research originated from 31 countries, however most countries (68%) had fewer than 10 articles published over the 23-year review period. In Review 2, we searched PubMed for records published between 2000 and 2023 with FASD, autism, or attention-deficit-hyperactivity disorder (ADHD) terms in the title. We compared the volume of records for these conditions using descriptive statistics and time-series plots. Of the 64,069 records retrieved, 2% were for FASD, compared to 60% for autism and 38% for ADHD. FASD remains considerably under-researched. While there has been an increase in the number of original FASD research articles published annually over time, this is much lower than expected compared to publication trends for other neurodevelopmental conditions, and the wider scientific literature. Further research is needed to understand the impact of FASD across the lifespan, to inform evidence-based policy and support, and to advance progress in strength-based, stigma-reducing approaches to FASD research and practice.
胎儿酒精谱系障碍（FASD）是全球神经发育障碍的主要原因。国际组织强调迫切需要改进预防、诊断和支持措施。然而，据认为为此提供依据的证据基础有限。我们进行了两项补充性综述，以（i）描述原始FASD研究文章的数量和特征趋势（综述1），以及（ii）将已发表的FASD研究数量与其他神经发育障碍的研究数量进行比较（综述2）。在综述1中，我们系统地检索了MEDLINE、Embase、CINAHL和PsycInfo，查找2000年至2023年期间标题中含有FASD术语的原始研究。我们使用定量内容分析和时间序列图总结了研究特征，包括文章主题、样本人群、原产国和出版年份。共有854项研究符合条件。与预防和干预相比，研究相对侧重于诊断和筛查。FASD研究来自31个国家，然而在23年的综述期内，大多数国家（68%）发表的文章少于10篇。在综述2中，我们在PubMed中搜索2000年至2023年期间标题中含有FASD、自闭症或注意力缺陷多动障碍（ADHD）术语的记录。我们使用描述性统计和时间序列图比较了这些病症的记录数量。在检索到的64,069条记录中，2%是关于FASD的，而自闭症为60%，ADHD为38%。FASD的研究仍然相当不足。虽然随着时间的推移，每年发表的原始FASD研究文章数量有所增加，但与其他神经发育病症的发表趋势以及更广泛的科学文献相比，这一数量远低于预期。需要进一步开展研究，以了解FASD在整个生命周期中的影响，为基于证据的政策和支持提供信息，并推动在以优势为基础、减少污名化的FASD研究和实践方面取得进展。
