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Bioregenerative autologous scaffold made from bone marrow aspirate concentrate, cancellous bone autograft, platelet-rich plasma, and autologous fibrin to treat non-unions of the femur, humerus, and forearm bones: a case series.由骨髓抽吸浓缩物、松质骨自体移植物、富血小板血浆和自体纤维蛋白制成的生物再生自体支架治疗股骨、肱骨和前臂骨不连：病例系列
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Quality of life changes in patients suffering from knee osteoarthritis treated with bone marrow aspirate concentrate, platelet-rich plasma and hyaluronic acid injections.接受骨髓抽吸浓缩物、富血小板血浆和透明质酸注射治疗的膝骨关节炎患者的生活质量变化
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Ilizarov method and its combined methods in the treatment of long bone defects of the lower extremity: systematic review and meta-analysis.伊里扎洛夫（Ilizarov）方法及其联合方法治疗下肢长骨缺损：系统评价和荟萃分析。
BMC Musculoskelet Disord. 2023 Nov 16;24(1):891. doi: 10.1186/s12891-023-07001-9.
2
Distraction osteogenesis versus induced membrane technique for infected tibial non-unions with segmental bone loss: a systematic review of the literature and meta-analysis of available studies.牵张成骨术与诱导膜技术治疗感染性胫骨骨不连伴节段性骨缺损：文献系统评价和现有研究的荟萃分析。
Eur J Trauma Emerg Surg. 2024 Jun;50(3):705-721. doi: 10.1007/s00068-023-02375-w. Epub 2023 Nov 3.
3
The role of osteoarthritis severity, BMI and age on clinical efficacy of bone marrow aspirate concentrate in the treatment of knee osteoarthritis.骨关节炎严重程度、BMI 和年龄对骨髓抽吸浓缩物治疗膝骨关节炎的临床疗效的影响。
Regen Med. 2023 Sep;18(9):735-747. doi: 10.2217/rme-2023-0042. Epub 2023 Aug 14.
4
The Concept of Scaffold-Guided Bone Regeneration for the Treatment of Long Bone Defects: Current Clinical Application and Future Perspective.用于治疗长骨缺损的支架引导骨再生概念：当前临床应用及未来展望
J Funct Biomater. 2023 Jun 27;14(7):341. doi: 10.3390/jfb14070341.
5
Factors Informing the Development of a Clinical Pathway and Patients' Quality of Life after a Non-Union Fracture of the Lower Limb.影响下肢骨折不愈合临床路径发展及患者生活质量的因素
Healthcare (Basel). 2023 Jun 20;11(12):1810. doi: 10.3390/healthcare11121810.
6
Autologous microfragmented adipose tissue and leukocyte-poor platelet-rich plasma combined with hyaluronic acid show comparable clinical outcomes for symptomatic early knee osteoarthritis over a two-year follow-up period: a prospective randomized clinical trial.自体微粉碎脂肪组织和贫白细胞富血小板血浆联合透明质酸治疗症状性早期膝骨关节炎的两年随访期临床疗效相当：一项前瞻性随机临床试验。
Eur J Orthop Surg Traumatol. 2023 Jul;33(5):1895-1904. doi: 10.1007/s00590-022-03356-2. Epub 2022 Aug 23.
7
Clinical translation of a patient-specific scaffold-guided bone regeneration concept in four cases with large long bone defects.四例大的长骨缺损患者特异性支架引导骨再生概念的临床转化
J Orthop Translat. 2022 Jun 16;34:73-84. doi: 10.1016/j.jot.2022.04.004. eCollection 2022 May.
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Biological and molecular profile of fracture non-union tissue: A systematic review and an update on current insights.骨折不愈合组织的生物学和分子特征：系统评价及最新研究进展。
J Cell Mol Med. 2022 Feb;26(3):601-623. doi: 10.1111/jcmm.17096. Epub 2022 Jan 4.
9
Analysis of Risk Factors for Non-union After Surgery for Limb Fractures: A Case-Control Study of 669 Subjects.肢体骨折术后骨不连危险因素分析：一项669例受试者的病例对照研究
Front Surg. 2021 Dec 14;8:754150. doi: 10.3389/fsurg.2021.754150. eCollection 2021.
10
Bone Marrow Aspirate Concentrate versus Platelet Rich Plasma or Hyaluronic Acid for the Treatment of Knee Osteoarthritis.骨髓抽吸浓缩物与富血小板血浆或透明质酸治疗膝骨关节炎的比较。
Medicina (Kaunas). 2021 Nov 2;57(11):1193. doi: 10.3390/medicina57111193.

利用骨髓抽吸浓缩物、松质骨自体移植物、富含血小板的血浆和自体纤维蛋白治疗股骨干骨不连的病例系列。

A case series utilizing bone marrow aspirate concentrate, cancellous bone autograft, platelet-rich plasma and autologous fibrin for the treatment of femur nonunions.

机构信息

Medical Faculty, University of Novi Sad,Serbia. University Clinical Center of Vojvodina.

Atlas Hospital, Belgrade, Serbia.

出版信息

Regen Med. 2024 May 3;19(5):225-237. doi: 10.1080/17460751.2024.2352250. Epub 2024 Jun 10.

DOI:10.1080/17460751.2024.2352250
PMID:39118529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11321269/
Abstract

To assess the efficacy of a bioregenerative scaffold derived from bone marrow aspirate, cancellous bone autograft, platelet-rich plasma and autologous fibrin in treating supracondylar femur nonunions. Three patients with nonunions following multiple surgical failures underwent bone stabilization and the application of a novel bioregenerative scaffold. x-rays and subjective scales were collected before surgery and at 6, 12 and 24 months post-surgery. All nonunions exhibited healing with sufficient callus formation, as confirmed radiologically. After 6 months, all patients resumed full weight-bearing walking without pain. Statistical analysis showed improvements in all scales compared with pre-surgical values. This method presents itself as an option for treating supracondylar femur nonunions following multiple surgical failures.

摘要

评估一种源自骨髓抽吸物、松质骨自体移植物、富含血小板的血浆和自体纤维蛋白的生物再生支架在治疗股骨髁上骨折不愈合中的疗效。三名在多次手术失败后发生不愈合的患者接受了骨稳定和新型生物再生支架的应用。在手术前和手术后 6、12 和 24 个月收集了 X 射线和主观量表。所有不愈合的病例均表现出愈合，有足够的骨痂形成，这在影像学上得到了证实。6 个月后，所有患者均无疼痛地恢复完全负重行走。统计分析显示与术前值相比，所有量表均有改善。这种方法为多次手术失败后治疗股骨髁上骨折不愈合提供了一种选择。