由骨髓抽吸浓缩物、松质骨自体移植物、富血小板血浆和自体纤维蛋白制成的生物再生自体支架治疗股骨、肱骨和前臂骨不连：病例系列

Bioregenerative autologous scaffold made from bone marrow aspirate concentrate, cancellous bone autograft, platelet-rich plasma, and autologous fibrin to treat non-unions of the femur, humerus, and forearm bones: a case series.

作者信息

Oliver Dulic, Dzihan Abazovic, Mirko Obradovic, Miodrag Vranjes, Ivica Lalic, Srdjan Ninkovic, Predrag Rasovic, Mile Bjelobrk, Branko Baljak, Milan Milinkov, Milan Tosic, Srdjan Sarac

机构信息

University of Novi Sad, Medical Faculty, University Clinical Center of Vojvodina, Novi Sad, Serbia.

Renova Hospital, Belgrade, Serbia.

出版信息

Regen Med. 2025 Apr;20(4):123-131. doi: 10.1080/17460751.2025.2507504. Epub 2025 May 20.

DOI:10.1080/17460751.2025.2507504

PMID:40391486

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12118442/

Abstract

AIM

To evaluate the effectiveness of a bioregenerative scaffold created from bone marrow aspirate, cancellous bone autograft, platelet-rich plasma, and autologous fibrin in treating complicated non-unions of the supracondylar femur, humeral shaft, and radius and ulna.

METHODS & MATERIALS: Three patients with non-unions resulting from multiple surgical failures underwent bone stabilization along with the application of a novel bioregenerative scaffold. X-rays and subjective assessments were collected prior to surgery and at 6- and 12-months post-surgery.

RESULTS

All non-unions demonstrated healing with adequate callus formation, as confirmed by radiological assessments. By 12 months, all patients were able to resume full weight-bearing activities or regain full range of motion and physical strength without pain. Statistical analysis revealed improvements across all assessment scales compared to pre-surgical values.