Hu Hongzhi, Xia Ling, Li Gongke, Chen Yi
School of Chemistry, Sun Yat-sen University, Guangzhou, China.
National & Local Joint Engineering Research Center for Mineral Salt Deep Utilization, Huaiyin Institute of Technology, Huaian, China.
J Sep Sci. 2024 Aug;47(15):e2400415. doi: 10.1002/jssc.202400415.
Porous cage materials with certain dimensions, sizes, shapes, and functions have been regarded as promising materials for sample preparation, chromatographic separation, and detection process. In contrast to infinite frameworks such as metal-organic frameworks or covalent organic frameworks, porous cage materials are constructed from discrete molecules containing at least one internal cavity. The well-defined cavities in porous cage materials provide opportunities for non-covalent interactions. These interactions can be programmed into the ligand design or supramolecular cage constructing using the cages as building blocks, offering various host-guest recognition with great selectivity. In this review, we desire to elucidate the fundamental principles governing the design and fabrication of porous cage materials with well-defined cavities, good solvent processability, and modifiable groups, the applications of these porous cage materials in sample preparation, chromatographic separation, and detection were discussed. The recent advantages of porous cage materials for the analysis process were summarized. We state the potential of these materials and provide an outlook for further application strategies. We expect that this review can inspire interest in the porous cage materials research area for analysis.
具有特定尺寸、大小、形状和功能的多孔笼状材料被视为用于样品制备、色谱分离和检测过程的有前景的材料。与金属有机框架或共价有机框架等无限框架不同，多孔笼状材料由包含至少一个内腔的离散分子构成。多孔笼状材料中明确界定的腔为非共价相互作用提供了机会。这些相互作用可以通过配体设计进行编程，或者使用笼作为构建块构建超分子笼，从而提供具有高选择性的各种主客体识别。在本综述中，我们希望阐明控制具有明确界定的腔、良好溶剂加工性和可修饰基团的多孔笼状材料的设计和制造的基本原理，讨论了这些多孔笼状材料在样品制备、色谱分离和检测中的应用。总结了多孔笼状材料在分析过程中的近期优势。我们阐述了这些材料的潜力，并为进一步的应用策略提供了展望。我们期望本综述能够激发对用于分析的多孔笼状材料研究领域的兴趣。
