Metformin: pioneering a path forward in knee osteoarthritis care?
作者信息
Anis Muhammad Wajeeh, Iqbal Arham, Younus Mohammad Ijlal, Aamir Ali, Khalid Waheedullah
机构信息
Dow International Medical College.
Dow Medical College, Karachi, Pakistan.
出版信息
Ann Med Surg (Lond). 2024 Jun 24;86(8):4333-4335. doi: 10.1097/MS9.0000000000002318. eCollection 2024 Aug.
Abstract
摘要
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Metformin Attenuates the Inflammatory Response via the Regulation of Synovial M1 Macrophage in Osteoarthritis.二甲双胍通过调节骨关节炎滑膜 M1 巨噬细胞减轻炎症反应。
Int J Mol Sci. 2023 Mar 10;24(6):5355. doi: 10.3390/ijms24065355.
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Metformin regulates chondrocyte senescence and proliferation through microRNA-34a/SIRT1 pathway in osteoarthritis.二甲双胍通过 microRNA-34a/SIRT1 通路调节骨关节炎软骨细胞衰老和增殖。
J Orthop Surg Res. 2023 Mar 13;18(1):198. doi: 10.1186/s13018-023-03571-5.
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Metformin Prevents or Delays the Development and Progression of Osteoarthritis: New Insight and Mechanism of Action.二甲双胍预防或延缓骨关节炎的发生和进展：新的见解和作用机制。
Cells. 2022 Sep 27;11(19):3012. doi: 10.3390/cells11193012.
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Metformin attenuates osteoarthritis by targeting chondrocytes, synovial macrophages and adipocytes.二甲双胍通过作用于软骨细胞、滑膜巨噬细胞和脂肪细胞来减轻骨关节炎。
Rheumatology (Oxford). 2023 Apr 3;62(4):1652-1661. doi: 10.1093/rheumatology/keac467.
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Metformin as a potential disease-modifying drug in osteoarthritis: a systematic review of pre-clinical and human studies.二甲双胍作为骨关节炎潜在的疾病修饰药物：临床前和人体研究的系统评价。
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