Xu Qiying, Liu Huifang, Song Xiaoyan, Wuren Tana, Ge Ri-Li
Research Center for High Altitude Medicine.
Key Laboratory for Application of High-Altitude Medicine, Qinghai University.
Ann Med Surg (Lond). 2024 May 17;86(8):4449-4455. doi: 10.1097/MS9.0000000000002126. eCollection 2024 Aug.
Myeloid-derived suppressor cells (MDSCs) are a subset of immature myeloid cells that inhibit anti-tumor immunity and contribute to poor cancer outcomes. In this study, the authors used multi-color flow cytometry to detect changes in MDSCs in patients with cancer and tumor-bearing mice. Then the authors studied changes in MDSCs ratio and mouse tumors after administration of hypoxia-inducible factor 1α (HIF-1α) inhibitor. The results showed that the ratio of MDSCs, specifically polymorphonuclear MDSCs (PMN-MDSCs), was higher in patients with cancer, and both PMN-MDSCs and monocytic MDSCs (M-MDSCs) ratio were higher in tumor-bearing mice. When provided with the HIF-1α inhibitor LW-6, the ratio of MDSCs decreased in tumor-bearing mice, particularly PMN-MDSCs, and the volume of liver metastases also decreased. The authors' findings suggest that reducing MDSCs by inhibiting hypoxia-inducible factor 1α may slow tumor progression.
髓源性抑制细胞（MDSCs）是未成熟髓细胞的一个亚群，可抑制抗肿瘤免疫并导致癌症预后不良。在本研究中，作者使用多色流式细胞术检测癌症患者和荷瘤小鼠体内MDSCs的变化。然后，作者研究了给予缺氧诱导因子1α（HIF-1α）抑制剂后MDSCs比例和小鼠肿瘤的变化。结果显示，癌症患者体内MDSCs的比例，特别是多形核MDSCs（PMN-MDSCs）较高，荷瘤小鼠体内PMN-MDSCs和单核细胞MDSCs（M-MDSCs）的比例均较高。当给予HIF-1α抑制剂LW-6时，荷瘤小鼠体内MDSCs的比例下降，尤其是PMN-MDSCs，肝转移瘤的体积也减小。作者的研究结果表明，通过抑制缺氧诱导因子1α来减少MDSCs可能会减缓肿瘤进展。
