Kudsi Maysoun, Drie Tasneem, Dumirieh Sumaya
Damascus University.
Department of Rheumatology, Faculty of Medicine, Damascus University, Damascus, Syrian Arab Republic.
Ann Med Surg (Lond). 2024 Jul 1;86(8):4932-4934. doi: 10.1097/MS9.0000000000002342. eCollection 2024 Aug.
Uveitis, as an extra-articular presentation, is found in 23% of patients with ankylosing spondylitis (AS) and is a challenging disease to treat.
The authors presented a 32-year-old male to the out-hospital, complaining of recurrent anterior uveitis 8 years earlier in his left eye, and suffered from inflammatory lumber pain for 2 years. So a diagnosis of AS after the failure of many therapeutic strategies, 50 mg /month subcutaneous Golimumab was started with clinical remission of AS and uveitis.
The American College of Rheumatology recommends the use of etanercept and adalimumab in the treatment of recurrent uveitis in AS patients. Similarly, the European League Against Rheumatism recommended using Infliximab, Adalimumab, or Certolizumab to prevent the recurrence of uveitis recurrence. Till now, a case about treating refractory uveitis with Golimumab in AS patients was published.
Golimumab was found to be effective in the treatment of uveitis associated with spondyloarthritis refractory at least one immunosuppressive drug.
葡萄膜炎作为一种关节外表现,在23%的强直性脊柱炎(AS)患者中出现,是一种治疗具有挑战性的疾病。
作者介绍了一名32岁男性,其8年前左眼反复出现前葡萄膜炎,并患有炎性腰背痛2年。在多种治疗策略失败后诊断为AS,开始每月皮下注射50毫克戈利木单抗,AS和葡萄膜炎临床缓解。
美国风湿病学会推荐使用依那西普和阿达木单抗治疗AS患者的复发性葡萄膜炎。同样,欧洲抗风湿病联盟推荐使用英夫利昔单抗、阿达木单抗或赛妥珠单抗预防葡萄膜炎复发。到目前为止,发表了一篇关于用戈利木单抗治疗AS患者难治性葡萄膜炎的病例。
发现戈利木单抗对治疗至少一种免疫抑制药物难治的脊柱关节炎相关葡萄膜炎有效。