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脓毒性休克管理的最新趋势:对当前证据和建议的叙述性综述

Recent trends in septic shock management: a narrative review of current evidence and recommendations.

作者信息

Nofal Mariam Akram, Shitawi Jawad, Altarawneh Hashem Bassam, Alrosan Sallam, Alqaisi Yanal, Al-Harazneh Al-Mothaffer, Alamaren Ammar Masoud, Abu-Jeyyab Mohammad

机构信息

School of Medicine, Jordan University Hospital, Amman, Jordan.

Internal Medicine, Epsom and St Helier University Hospitals NHS Trust, Sutton, GBR, UK.

出版信息

Ann Med Surg (Lond). 2024 May 15;86(8):4532-4540. doi: 10.1097/MS9.0000000000002048. eCollection 2024 Aug.

Abstract

Septic shock stands for a group of manifestations that will cause a severe hemodynamic and metabolic dysfunction, which leads to a significant increase in the risk of death by a massive response of the immune system to any sort of infection that ends up with refractory hypotension making it responsible for escalating the numbers of hospitalized patients mortality rate, Organisms that are isolated most of the time are , and . The WHO considers sepsis to be a worldwide health concern; the incidence of sepsis and septic shock have been increasing over the years while being considered to be under-reported at the same time. This review is a quick informative recap of the recent studies regarding diagnostic approaches using lactic acid (Lac), procalcitonin (PCT), Sequential Organ Failure Assessment (SOFA) score, acute physiology and chronic health evaluation II (APACHE II) score, as well as management recommendations for using vasopressors, fluid resuscitation, corticosteroids and antibiotics that should be considered when dealing with such type of shock.

摘要

感染性休克是一组会导致严重血流动力学和代谢功能障碍的表现,这会因免疫系统对任何类型感染的大规模反应而导致死亡风险显著增加,最终导致难治性低血压,使其成为住院患者死亡率上升的原因。大多数时候分离出的病原体是……和……。世界卫生组织认为脓毒症是一个全球健康问题;脓毒症和感染性休克的发病率多年来一直在上升,同时被认为报告不足。本综述是对近期关于使用乳酸(Lac)、降钙素原(PCT)、序贯器官衰竭评估(SOFA)评分、急性生理与慢性健康状况评估II(APACHE II)评分的诊断方法的快速信息性总结,以及在处理此类休克时应考虑使用血管加压药、液体复苏、皮质类固醇和抗生素的管理建议。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/001e/11305747/2054805c861a/ms9-86-4532-g001.jpg

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