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胰腺导管腺癌中神经周围浸润的特征：新的生物学层面

Hallmarks of perineural invasion in pancreatic ductal adenocarcinoma: new biological dimensions.

作者信息

Sun Yaquan, Jiang Wei, Liao Xiang, Wang Dongqing

机构信息

Institute of Medical Imaging and Artificial Intelligence, Jiangsu University, Zhenjiang, China.

Department of Medical Imaging, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.

出版信息

Front Oncol. 2024 Jul 25;14:1421067. doi: 10.3389/fonc.2024.1421067. eCollection 2024.

DOI:10.3389/fonc.2024.1421067
PMID:39119085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11307098/
Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant tumor with a high metastatic potential. Perineural invasion (PNI) occurs in the early stages of PDAC with a high incidence rate and is directly associated with a poor prognosis. It involves close interaction among PDAC cells, nerves and the tumor microenvironment. In this review, we detailed discuss PNI-related pain, six specific steps of PNI, and treatment of PDAC with PNI and emphasize the importance of novel technologies for further investigation.

摘要

胰腺导管腺癌（PDAC）是一种具有高转移潜能的侵袭性恶性肿瘤。神经周围侵犯（PNI）在PDAC早期阶段发生率很高，且与预后不良直接相关。它涉及PDAC细胞、神经和肿瘤微环境之间的密切相互作用。在本综述中，我们详细讨论了与PNI相关的疼痛、PNI的六个具体步骤以及伴有PNI的PDAC的治疗，并强调了新技术对进一步研究的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f87e/11307098/2fdd4c68a112/fonc-14-1421067-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f87e/11307098/8e24145c32ed/fonc-14-1421067-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f87e/11307098/974f570e253a/fonc-14-1421067-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f87e/11307098/9295516e593e/fonc-14-1421067-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f87e/11307098/2fdd4c68a112/fonc-14-1421067-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f87e/11307098/8e24145c32ed/fonc-14-1421067-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f87e/11307098/974f570e253a/fonc-14-1421067-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f87e/11307098/9295516e593e/fonc-14-1421067-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f87e/11307098/2fdd4c68a112/fonc-14-1421067-g004.jpg

相似文献

[1]
Hallmarks of perineural invasion in pancreatic ductal adenocarcinoma: new biological dimensions.

Front Oncol. 2024-7-25

[2]
The Key Genes for Perineural Invasion in Pancreatic Ductal Adenocarcinoma Identified With Monte-Carlo Feature Selection Method.

Front Genet. 2020-10-15

[3]
Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma.

Cancer Commun (Lond). 2021-8

[4]
Perineural Invasion in Pancreatic Ductal Adenocarcinoma: From Molecules towards Drugs of Clinical Relevance.

Cancers (Basel). 2022-11-24

[5]
Neural Component of the Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma.

Cancers (Basel). 2022-10-26

[6]
Perineural Invasion and Associated Pain Transmission in Pancreatic Cancer.

Cancers (Basel). 2021-9-13

[7]
Targeting the Cancer-Neuronal Crosstalk in the Pancreatic Cancer Microenvironment.

Int J Mol Sci. 2023-10-8

[8]
Quantification of perineural invasion in pancreatic ductal adenocarcinoma: proposal of a severity score system.

Virchows Arch. 2023-8

[9]
Perineural and intraneural invasion in posttherapy pancreaticoduodenectomy specimens predicts poor prognosis in patients with pancreatic ductal adenocarcinoma.

Am J Surg Pathol. 2012-3

[10]
Perineural invasion in pancreatic cancer: proteomic analysis and in vitro modelling.

Mol Oncol. 2019-3-5

引用本文的文献

[1]
Perineural invasion and the "cold" tumor microenvironment in pancreatic cancer: mechanisms of crosstalk and therapeutic opportunities.

Front Immunol. 2025-8-20

本文引用的文献

[1]
Cancer statistics, 2024.

CA Cancer J Clin. 2024

[2]
Perineural invasion in colorectal cancer: mechanisms of action and clinical relevance.

Cell Oncol (Dordr). 2024-2

[3]
Perineural invasion detection in pancreatic ductal adenocarcinoma using artificial intelligence.

Sci Rep. 2023-8-21

[4]
BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis.

Signal Transduct Target Ther. 2023-7-14

[5]
Nanoparticle-mediated TRPV1 channel blockade amplifies cancer thermo-immunotherapy via heat shock factor 1 modulation.

Nat Commun. 2023-4-29

[6]
Pancreatic cancer: Advances and challenges.

Cell. 2023-4-13

[7]
Metastasis.

Cell. 2023-4-13

[8]
Important Cells and Factors from Tumor Microenvironment Participated in Perineural Invasion.

Cancers (Basel). 2023-2-21

[9]
Cell-extracellular matrix mechanotransduction in 3D.

Nat Rev Mol Cell Biol. 2023-7

[10]
Harnessing prostaglandin E signaling to ameliorate autoimmunity.

Trends Immunol. 2023-3

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