胰腺导管腺癌中神经周围浸润的特征：新的生物学层面
Hallmarks of perineural invasion in pancreatic ductal adenocarcinoma: new biological dimensions.
作者信息
Sun Yaquan, Jiang Wei, Liao Xiang, Wang Dongqing
机构信息
Institute of Medical Imaging and Artificial Intelligence, Jiangsu University, Zhenjiang, China.
Department of Medical Imaging, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
出版信息
Front Oncol. 2024 Jul 25;14:1421067. doi: 10.3389/fonc.2024.1421067. eCollection 2024.
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant tumor with a high metastatic potential. Perineural invasion (PNI) occurs in the early stages of PDAC with a high incidence rate and is directly associated with a poor prognosis. It involves close interaction among PDAC cells, nerves and the tumor microenvironment. In this review, we detailed discuss PNI-related pain, six specific steps of PNI, and treatment of PDAC with PNI and emphasize the importance of novel technologies for further investigation.
胰腺导管腺癌（PDAC）是一种具有高转移潜能的侵袭性恶性肿瘤。神经周围侵犯（PNI）在PDAC早期阶段发生率很高，且与预后不良直接相关。它涉及PDAC细胞、神经和肿瘤微环境之间的密切相互作用。在本综述中，我们详细讨论了与PNI相关的疼痛、PNI的六个具体步骤以及伴有PNI的PDAC的治疗，并强调了新技术对进一步研究的重要性。
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