转移。
Metastasis.
机构信息
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
出版信息
Cell. 2023 Apr 13;186(8):1564-1579. doi: 10.1016/j.cell.2023.03.003.
Abstract
Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still emerging. Metastasis requires the acquisition of a succession of traits to disseminate, variably enter and exit dormancy, and colonize distant organs. The success of these events is driven by clonal selection, the potential of metastatic cells to dynamically transition into distinct states, and their ability to co-opt the immune environment. Here, we review the main principles of metastasis and highlight emerging opportunities to develop more effective therapies for metastatic cancer.
摘要
大多数与癌症相关的死亡是由于转移导致的，然而，我们对于转移作为一种不断演变的、异质的、系统性疾病的理解，以及如何有效地治疗它，仍在不断发展中。转移需要连续获得一系列特性，以便传播、有差异地进入和退出休眠状态，并在远处器官定植。这些事件的成功是由克隆选择驱动的，即转移性细胞动态转变为不同状态的潜力，以及它们能够利用免疫环境的能力。在这里，我们回顾了转移的主要原则，并强调了开发更有效的转移性癌症治疗方法的新机会。
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2
Epigenetics as a mediator of plasticity in cancer.表观遗传学作为癌症可塑性的介体。
Science. 2023 Feb 10;379(6632):eaaw3835. doi: 10.1126/science.aaw3835.
3
Slow TCA flux and ATP production in primary solid tumours but not metastases.原发性实体瘤而非转移瘤中 TCA 循环缓慢和 ATP 生成减少。
Nature. 2023 Feb;614(7947):349-357. doi: 10.1038/s41586-022-05661-6. Epub 2023 Feb 1.
4
Outcomes and clinicopathologic characteristics associated with disseminated tumor cells in bone marrow after neoadjuvant chemotherapy in high-risk early stage breast cancer: the I-SPY SURMOUNT study.新辅助化疗后高危早期乳腺癌骨髓中播散肿瘤细胞的结果和临床病理特征：I-SPY SURMOUNT 研究。
Breast Cancer Res Treat. 2023 Apr;198(2):383-390. doi: 10.1007/s10549-022-06803-0. Epub 2023 Jan 23.
5
The next generation of evidence-based medicine.循证医学的下一代。
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Nat Rev Clin Oncol. 2023 Mar;20(3):192-206. doi: 10.1038/s41571-022-00721-2. Epub 2023 Jan 12.
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