Department of Regulatory and Forensic Toxicology, Institute of Medical Expertises in Łódź, Ul. Aleksandrowska 67/93, 91-205 Łódź, Poland.
Laboratory of Innovative Toxicological Research and Analyzes, Institute of Medical Studies, Medical College, Rzeszów University, Al. Mjr. W. Kopisto 2a, 35-959 Rzeszów, Poland.
Chem Res Toxicol. 2024 Nov 18;37(11):1821-1842. doi: 10.1021/acs.chemrestox.4c00105. Epub 2024 Aug 9.
Bromo-DragonFLY is a synthetic new psychoactive substance (NPS) that has gained attention due to its powerful and long-lasting hallucinogenic effects, legal status, and widespread availability. This study aimed to use various toxicology methods to predict key toxicological parameters for Bromo-DragonFLY, including acute toxicity (LD), genotoxicity, cardiotoxicity, health effects, and the potential for endocrine disruption. The results indicate significant acute toxicity with noticeable variations across different species, a low likelihood of genotoxic potential suggesting potential DNA damage, and a notable risk of cardiotoxicity associated with inhibition of the hERG channel. Evaluation of endocrine disruption suggests a low probability of Bromo-DragonFLY interacting with the estrogen receptor α (ER-α), indicating minimal estrogenic activity. These insights from investigations are important for advancing our understanding of this NPS in forensic and clinical toxicology. These initial toxicological examinations establish a foundation for future research efforts and contribute to developing risk assessment and management strategies for using and misusing NPS.
Bromo-DragonFLY 是一种新型合成精神活性物质（NPS），因其强大而持久的致幻作用、合法地位和广泛的可用性而受到关注。本研究旨在使用各种毒理学方法预测 Bromo-DragonFLY 的关键毒理学参数，包括急性毒性 (LD)、遗传毒性、心脏毒性、健康影响和内分泌干扰的潜力。结果表明其具有显著的急性毒性，不同物种之间存在明显差异，遗传毒性的可能性较低，表明可能存在 DNA 损伤，与 hERG 通道抑制相关的心脏毒性风险显著。内分泌干扰评估表明 Bromo-DragonFLY 与雌激素受体 α（ER-α）相互作用的可能性较低，表明其雌激素活性较小。这些来自调查的见解对于我们在法医和临床毒理学中对这种 NPS 的理解很重要。这些初步的毒理学研究为未来的研究工作奠定了基础，并有助于制定使用和滥用 NPS 的风险评估和管理策略。
