无金属条件下光氧化还原催化的3-亚甲基异吲哚啉-1-酮的C(sp)-H三氟甲基化反应
Photoredox-catalyzed C(sp)-H trifluoromethylation of 3-methylene-isoindolin-1-ones under metal-free conditions.
作者信息
Zhou Yuan-Xia, Liu Feng-Qian, Wang Guo-Qin, Yang Dan, Han Pan, Jing Lin-Hai
机构信息
Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China.
出版信息
Org Biomol Chem. 2024 Aug 28;22(34):6928-6932. doi: 10.1039/d4ob01046a.
A facile synthetic method for direct C(sp)-H bond trifluoromethylation of 3-methylene-isoindolin-1-ones under visible-light-induced metal-free conditions is presented. This protocol features mild reaction conditions, broad substrate scope and excellent functional group tolerance, resulting in a range of structurally diverse trifluoromethylated products in good to excellent yields.
本文提出了一种在可见光诱导的无金属条件下，对3-亚甲基异吲哚啉-1-酮进行直接C(sp)-H键三氟甲基化的简便合成方法。该方法具有反应条件温和、底物范围广和官能团耐受性好的特点，能以良好至优异的产率得到一系列结构多样的三氟甲基化产物。
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