Zhou Yuan-Xia, Liu Feng-Qian, Wang Guo-Qin, Yang Dan, Han Pan, Jing Lin-Hai
Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China.
Org Biomol Chem. 2024 Aug 28;22(34):6928-6932. doi: 10.1039/d4ob01046a.
A facile synthetic method for direct C(sp)-H bond trifluoromethylation of 3-methylene-isoindolin-1-ones under visible-light-induced metal-free conditions is presented. This protocol features mild reaction conditions, broad substrate scope and excellent functional group tolerance, resulting in a range of structurally diverse trifluoromethylated products in good to excellent yields.
本文提出了一种在可见光诱导的无金属条件下，对3-亚甲基异吲哚啉-1-酮进行直接C(sp)-H键三氟甲基化的简便合成方法。该方法具有反应条件温和、底物范围广和官能团耐受性好的特点，能以良好至优异的产率得到一系列结构多样的三氟甲基化产物。
